The effect of the calcium channel blocker nimodipine on hippocampal BDNF/Ach levels in rats with experimental cognitive impairment
Sign Up to like & getrecommendations! Published in 2023 at "Neurological Research"
DOI: 10.1080/01616412.2022.2164452
Abstract: ABSTRACT Objective Alzheimer’s disease (AD) occurs in approximately 10% to 30% of individuals aged 65 or older worldwide. Novel therapeutic agents therefore need to be discovered in addition to traditional medications. Nimodipine appears to possess… read more here.
Keywords: cognitive impairment; day; nimodipine; bdnf ach ... See more keywords
Nimodipine accelerates the restoration of functional hyperemia during spreading oligemia.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of neurochemistry"
DOI: 10.1111/jnc.15792
Abstract: Spreading depolarization (SD) is assumed to be the pathophysiological correlate of migraine aura, leading to spreading depression of activity and a long-lasting vasoconstriction known as spreading oligemia. Further, cerebrovascular reactivity is reversibly impaired after SD.… read more here.
Keywords: functional hyperemia; nimodipine; spreading oligemia; nimodipine accelerates ... See more keywords
Nimodipine Reappraised: An Old Drug with a Future
Sign Up to like & getrecommendations! Published in 2019 at "Current Neuropharmacology"
DOI: 10.2174/1570159x17666190927113021
Abstract: Nimodipine is a dihydropyridine calcium channel antagonist that blocks the flux of extracellular calcium through L-type, voltage-gated calcium channels. While nimodipine is FDA-approved for the prevention and treatment of neurological deficits in patients with aneurysmal… read more here.
Keywords: drug; old drug; nimodipine; nimodipine reappraised ... See more keywords
FORMULATION, DEVELOPMENT AND CHARACTERISATION OF NIMODIPINE LOADED SOLID LIPID NANOPARTICLES
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Applied Pharmaceutics"
DOI: 10.22159/ijap.2020v12i5.34342
Abstract: Objective: The aim of the present study is to develop solid lipid nanoparticles (SLNs) of Nimodipine using hot homogenization followed by ultrasonication technique and to improve the dissolution characteristics of the drug. Methods: The Nimodipine-loaded… read more here.
Keywords: nimodipine; drug; lipid nanoparticles; nimodipine loaded ... See more keywords
Nimodipine augments cerebrovascular reactivity in aging but runs the risk of local perfusion reduction in acute cerebral ischemia
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2023.1175281
Abstract: Introduction The efficacy of cerebrovascular reactivity (CVR) is taken as an indicator of cerebrovascular health. Methods and Results We found that CVR tested with the inhalation of 10 % CO2 declined in the parietal cortex… read more here.
Keywords: ischemia; cerebrovascular reactivity; cerebral ischemia; nimodipine ... See more keywords
Adverse Events and Complications in Continuous Intra-arterial Nimodipine Infusion Therapy After Aneurysmal Subarachnoid Hemorrhage
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2021.812898
Abstract: Objective To determine the frequency and severity of complications associated with the continuous intra-arterial infusion of nimodipine (CIANI) as a new treatment of delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (SAH). Methods Patients from… read more here.
Keywords: intra arterial; hemorrhage; aneurysmal subarachnoid; subarachnoid hemorrhage ... See more keywords
Protective Effect of Nimodipine Against Valproic-acid Induced Biochemical and Behavioral Phenotypes of Autism
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Psychopharmacology and Neuroscience"
DOI: 10.9758/cpn.2022.20.4.725
Abstract: Objective Present study was designed to investigate behavioral and biochemical role of nimodipine in prenatal valproic acid (Pre-VPA) induced autism in rats. Methods Valproic acid was utilized to induce autistic phenotypes in Wistar rats. The… read more here.
Keywords: autism; valproic acid; nimodipine; pre vpa ... See more keywords