Kinetically Controllable Construction of Nine-Membered Carbocycles via Pd-Catalyzed Decarboxylative Cycloaddition.
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DOI: 10.1021/acs.orglett.2c00808
Abstract: A kinetically controllable strategy toward the construction of otherwise challenging nine-membered carbocycles is reported. This Pd-catalyzed decarboxylative procedure utilizes vinyl methylene cyclic carbonates as the C5-dipole and allylidenemalononitriles as C4-building blocks. The protocol features user-friendly… read more here.
Keywords: kinetically controllable; nine membered; membered carbocycles; controllable construction ... See more keywords
Hydride Transfer-Initiated Cross-Dehydrogenative Coupling Reaction to Access Nine-Membered Rings.
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DOI: 10.1021/acs.orglett.3c00193
Abstract: An unprecedented hydride transfer-triggered cross-dehydrogenative coupling of two C(sp3)-H bonds to target nine-membered rings has been developed. Salient features of this methodology include atom and step economy and metal-free and redox-neutral conditions, with water as… read more here.
Keywords: nine membered; membered rings; hydride transfer; dehydrogenative coupling ... See more keywords
Nine-Membered Ketolactams by Oxidative Cyclization Expansion.
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DOI: 10.1021/acs.orglett.5c01462
Abstract: Considerable progress has been made over decades in synthetic organic chemistry in order to build up molecular complexity, often through the design of advanced catalytic systems. Yet, simply exposing organic molecules to benchmark oxidants in… read more here.
Keywords: cyclization expansion; nine membered; ketolactams oxidative; oxidative cyclization ... See more keywords