Characterization of Enzymes Involved in Nintedanib Metabolism in Humans
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DOI: 10.1124/dmd.122.001113
Abstract: Nintedanib, which is used to treat idiopathic pulmonary fibrosis and non–small cell lung cancer, is metabolized to a pharmacologically inactive carboxylate derivative, BIBF1202, via hydrolysis and subsequently by glucuronidation to BIBF1202 acyl-glucuronide (BIBF1202-G). Since BIBF1202-G… read more here.
Keywords: glucuronidation; min per; nintedanib metabolism; bibf1202 ... See more keywords