Gene end-like sequences within the 3' non-coding region of the Nipah virus genome attenuate viral gene transcription.
Sign Up to like & getrecommendations! Published in 2017 at "Virology"
DOI: 10.1016/j.virol.2017.05.004
Abstract: The regulation of transcription during Nipah virus (NiV) replication is poorly understood. Using a bicistronic minigenome system, we investigated the involvement of non-coding regions (NCRs) in the transcriptional re-initiation efficiency of NiV RNA polymerase. Reporter… read more here.
Keywords: transcription; nipah virus; non coding; gene end ... See more keywords
Rabies-based vaccine induces potent immune responses against Nipah virus
Sign Up to like & getrecommendations! Published in 2019 at "NPJ Vaccines"
DOI: 10.1038/s41541-019-0109-5
Abstract: Nipah Virus (NiV) is a re-emerging zoonotic pathogen in the genus Henipavirus of the Paramyxoviridae family of viruses. NiV is endemic to Bangladesh and Malaysia and is highly fatal to both livestock and humans (human… read more here.
Keywords: rabies virus; nipah virus; niv specific; niv glycoprotein ... See more keywords
Nipah virus dynamics in bats and implications for spillover to humans
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2000429117
Abstract: Significance Nipah virus (NiV) is a zoonotic virus and World Health Organization (WHO) priority pathogen that causes near-annual outbreaks in Bangladesh and India with >75% mortality. This work advances our understanding of transmission of NiV… read more here.
Keywords: nipah virus; transmission; spillover humans; dynamics bats ... See more keywords
A recombinant VSV-vectored vaccine rapidly protects nonhuman primates against lethal Nipah virus disease
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2200065119
Abstract: Significance Concern has increased about the pandemic potential of Nipah virus (NiV). Similar to SARS-CoV-2, NiV is an RNA virus that is transmitted by respiratory droplets. There are currently no NiV vaccines licensed for human… read more here.
Keywords: vsv vectored; recombinant vsv; vectored vaccine; virus ... See more keywords
Novel Roles of the Nipah Virus Attachment Glycoprotein and Its Mobility in Early and Late Membrane Fusion Steps
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DOI: 10.1128/mbio.03222-21
Abstract: The important Paramyxoviridae family includes measles, mumps, human parainfluenza, and the emerging deadly zoonotic Nipah virus (NiV) and Hendra virus (HeV). The deadly emerging NiV can cause neurologic and respiratory symptoms in humans with a >60%… read more here.
Keywords: fusion; membrane fusion; nipah virus; fusion pore ... See more keywords
Defective Interfering Viral Particle Treatment Reduces Clinical Signs and Protects Hamsters from Lethal Nipah Virus Disease
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DOI: 10.1128/mbio.03294-21
Abstract: Here, we demonstrate that treatment with defective interfering particles (DIs), a natural by-product of viral infection, can significantly improve the clinical course and outcome of viral disease. When present with their parental virus, DIs can… read more here.
Keywords: defective interfering; disease; virus disease; nipah virus ... See more keywords
Hendra and Nipah Virus Infection in Cultured Human Olfactory Epithelial Cells
Sign Up to like & getrecommendations! Published in 2017 at "mSphere"
DOI: 10.1128/msphere.00252-17
Abstract: Henipaviruses are emerging zoonotic pathogens that can cause acute and severe respiratory and neurological disease in humans. The pathways by which henipaviruses enter the central nervous system (CNS) in humans are still unknown. The observation… read more here.
Keywords: nipah virus; infection; human olfactory; cns ... See more keywords
Development of a novel real-time polymerase chain reaction assay for the quantitative detection of Nipah virus replicative viral RNA
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0199534
Abstract: Nipah virus (NiV) is a highly pathogenic zoonotic paramyxovirus that can result in severe pulmonary disease and fatal encephalitis in humans and is responsible for outbreaks in Bangladesh, Malaysia, Singapore, India and possibly the Philippines.… read more here.
Keywords: polymerase chain; chain reaction; nipah virus; real time ... See more keywords
Nipah virus induces two inclusion body populations: Identification of novel inclusions at the plasma membrane
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DOI: 10.1371/journal.ppat.1007733
Abstract: Formation of cytoplasmic inclusion bodies (IBs) is a hallmark of infections with non-segmented negative-strand RNA viruses (order Mononegavirales). We show here that Nipah virus (NiV), a bat-derived highly pathogenic member of the Paramyxoviridae family, differs… read more here.
Keywords: inclusion; nipah virus; identification novel; membrane ... See more keywords
Recombinant vesicular stomatitis vaccine against Nipah virus has a favorable safety profile: Model for assessment of live vaccines with neurotropic potential
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010658
Abstract: Nipah virus (NiV) disease is a bat-borne zoonosis responsible for outbreaks with high lethality and is a priority for vaccine development. With funding from the Coalition of Epidemic Preparedness Innovations (CEPI), we are developing a… read more here.
Keywords: adult; profile; nipah virus; recombinant vesicular ... See more keywords
Evaluation of three rapid low-resource molecular tests for Nipah virus
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.1101914
Abstract: Accurate and timely diagnosis of Nipah virus (NiV) requires rapid, inexpensive, and robust diagnostic tests to control spread of disease. Current state of the art technologies are slow and require laboratory infrastructure that may not… read more here.
Keywords: evaluation three; three rapid; low resource; rapid low ... See more keywords