Trastuzumab‐based near‐infrared photoimmunotherapy in xenograft mouse of breast cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5302
Abstract: Near‐infrared photoimmunotherapy (NIR‐PIT) is a novel form of cancer treatment using conjugates of antibody against overexpressed antigens in cancers and photoabsorber IRDye700DX. HER2 is overexpressed in various cancers, for which molecular targeted therapy such as… read more here.
Keywords: breast cancer; tra ir700; cancer; nir pit ... See more keywords
Near-infrared photoimmunotherapy targeting human-EGFR in a mouse tumor model simulating current and future clinical trials
Sign Up to like & getrecommendations! Published in 2021 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2021.103345
Abstract: Background near-infrared photoimmunotherapy (NIR-PIT) is a cancer treatment that uses antibody-photoabsorber (IRDye700DX, IR700) conjugates (APCs) which bind to target cells and are photoactivated by NIR light inducing rapid necrotic cell death. NIR-PIT targeting human epidermal… read more here.
Keywords: pit; nir pit; hegfr; cd25 ... See more keywords
Near-infrared photoimmunotherapy for the treatment of skin disorders
Sign Up to like & getrecommendations! Published in 2021 at "Expert Opinion on Biological Therapy"
DOI: 10.1080/14712598.2022.2012147
Abstract: ABSTRACT Introduction Near-Infrared Photoimmunotherapy (NIR-PIT) is a novel molecularly targeted phototherapy. This technique is based on a conjugate of a near-infrared photo-inducible molecule (antibody-photon absorber conjugate, APC) and a monoclonal antibody that targets a tumor-specific… read more here.
Keywords: skin disorders; infrared photoimmunotherapy; nir pit; treatment skin ... See more keywords
CD29 targeted near-infrared photoimmunotherapy (NIR-PIT) in the treatment of a pigmented melanoma model
Sign Up to like & getrecommendations! Published in 2022 at "Oncoimmunology"
DOI: 10.1080/2162402x.2021.2019922
Abstract: ABSTRACT Near-infrared photoimmunotherapy (NIR-PIT) is a newly developed cancer treatment that utilizes an antibody-photoabsorber-conjugate (AbPC) combined with NIR light. The AbPC is injected and binds to the tumor whereupon NIR light irradiation causes a photochemical… read more here.
Keywords: cd29; cd29 pit; nir pit; treatment ... See more keywords
Selective depletion of polymorphonuclear myeloid derived suppressor cells in tumor beds with near infrared photoimmunotherapy enhances host immune response
Sign Up to like & getrecommendations! Published in 2022 at "Oncoimmunology"
DOI: 10.1080/2162402x.2022.2152248
Abstract: ABSTRACT The immune system is recognized as an important factor in regulating the development, progression, and metastasis of cancer. Myeloid-derived suppressor cells (MDSCs) are a major immune-suppressive cell type by interfering with T cell activation,… read more here.
Keywords: cell; myeloid derived; derived suppressor; nir pit ... See more keywords
Abstract 5110: Locally administered Interleukin-15 combined with cancer cell-targeted near-infrared photoimmunotherapy in a syngeneic mouse cancer model
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5110
Abstract: Near-infrared photoimmunotherapy (NIR-PIT) is a new anti-cancer treatment by NIR light-induced photochemical reactions within antibody-IRdye700DX conjugates, leading to significant immunogenic cell death. The efficacy of NIR-PIT is synergistically enhanced by combining immune activating agents including… read more here.
Keywords: cell; mc38; nir pit; tumor ... See more keywords
Syngeneic Mouse Models of Oral Cancer Are Effectively Targeted by Anti–CD44-Based NIR-PIT
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DOI: 10.1158/1541-7786.mcr-17-0333
Abstract: Oral cavity squamous cell carcinoma (OSCC) is considered one of the most aggressive subtypes of cancer. Anti-CD44 monoclonal antibodies (mAb) are a potential therapy against CD44 expressing OSCC; however, to date the therapeutic effects have… read more here.
Keywords: cd44 ir700; nir pit; anti cd44; cd44 ... See more keywords
Host Immunity Following Near-Infrared Photoimmunotherapy Is Enhanced with PD-1 Checkpoint Blockade to Eradicate Established Antigenic Tumors
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-18-0546
Abstract: PD-1 blockade reverses adaptive immune resistance following near-infrared photoimmunotherapy to enhance polyclonal T-cell responses, causing rejection of established syngeneic tumors in both treated and distant untreated tumors. These responses also enhanced immunologic memory development that… read more here.
Keywords: nir pit; near infrared; cell; tumor ... See more keywords
Quantitative analysis of vascular changes during photoimmunotherapy using speckle variance optical coherence tomography (SV-OCT).
Sign Up to like & getrecommendations! Published in 2021 at "Biomedical optics express"
DOI: 10.1364/boe.419163
Abstract: Near-infrared (NIR) photoimmunotherapy (NIR-PIT) is an emerging cancer therapy based on a monoclonal antibody and phthalocyanine dye conjugate. Direct tumor necrosis and immunogenic cell death occur during NIR irradiation. However, the alteration of tumor blood… read more here.
Keywords: nir pit; optical coherence; blood; speckle variance ... See more keywords
Avoiding thermal injury during near-infrared photoimmunotherapy (NIR-PIT): the importance of NIR light power density
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.20179
Abstract: Near-infrared photoimmunotherapy (NIR-PIT) is a newly-established cancer treatment which employs the combination of an antibody-photoabsorber conjugate (APC) and NIR light. When NIR light is absorbed by APC-bound tissues, a certain amount of heat is generated… read more here.
Keywords: pit; nir light; power density; nir pit ... See more keywords
Hurdles for the wide implementation of photoimmunotherapy.
Sign Up to like & getrecommendations! Published in 2021 at "Immunotherapy"
DOI: 10.2217/imt-2021-0241
Abstract: Near infrared photoimmunotherapy (NIR-PIT) is a molecularly targeted treatment for cancers achieved by injecting a conjugate of IRDye700DX® (IR700), a water-soluble silicon phthalocyanine derivative in the near infrared, and a monoclonal antibody that targets cancer… read more here.
Keywords: hurdles wide; nir pit; implementation; near infrared ... See more keywords