Safely Prescribing Nirmatrelvir and Ritonavir-Avoiding Drug-Drug Interactions.
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DOI: 10.1001/jamainternmed.2022.6834
Abstract: This Teachable Moment discusses drug-drug interactions with nirmatrelvir and ritonavir (Paxlovid) treatment for COVID-19 and considerations when prescribing. read more here.
Keywords: drug interactions; drug drug; nirmatrelvir ritonavir; safely prescribing ... See more keywords
Drug Interactions With Nirmatrelvir-Ritonavir in Older Adults Using Multiple Medications
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DOI: 10.1001/jamanetworkopen.2022.20184
Abstract: This quality improvement study uses data from the MedSafer trial to evaluate drug-drug interactions between nirmatrelvir-ritonavir and maintenance medications to identify use of potentially inappropriate medications in older adults with polypharmacy. read more here.
Keywords: ritonavir older; older adults; drug interactions; nirmatrelvir ritonavir ... See more keywords
Prevalence of Contraindications to Nirmatrelvir-Ritonavir Among Hospitalized Patients With COVID-19 at Risk for Progression to Severe Disease
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DOI: 10.1001/jamanetworkopen.2022.42140
Abstract: This cohort study examines the prevalence of contraindications to nirmatrelvir-ritonavir in patients hospitalized with COVID-19. read more here.
Keywords: ritonavir among; contraindications nirmatrelvir; nirmatrelvir ritonavir; among hospitalized ... See more keywords
Incidence of Viral Rebound After Treatment With Nirmatrelvir-Ritonavir and Molnupiravir
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DOI: 10.1001/jamanetworkopen.2022.45086
Abstract: Key Points Question What is the incidence of viral rebound after treatment with nirmatrelvir-ritonavir and molnupiravir? Findings In this cohort study of 12 629 adults in Hong Kong with COVID-19 who were hospitalized and had serial… read more here.
Keywords: nirmatrelvir ritonavir; ritonavir molnupiravir; viral rebound; treatment nirmatrelvir ... See more keywords
Clinical Outcomes Following Treatment for COVID-19 With Nirmatrelvir/Ritonavir and Molnupiravir Among Patients Living in Nursing Homes
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DOI: 10.1001/jamanetworkopen.2023.10887
Abstract: Key Points Question What is the association between the use of 2 oral antivirals, molnupiravir and nirmatrelvir/ritonavir, and the risk of hospitalization and inpatient disease progression among patients with COVID-19 living in nursing homes? Findings… read more here.
Keywords: nursing homes; patients living; nirmatrelvir ritonavir; living nursing ... See more keywords
Analysis of All-Cause Hospitalization and Death Among Nonhospitalized Patients With Type 2 Diabetes and SARS-CoV-2 Infection Treated With Molnupiravir or Nirmatrelvir-Ritonavir During the Omicron Wave in Hong Kong
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DOI: 10.1001/jamanetworkopen.2023.14393
Abstract: Key Points Question Are oral antiviral medications such as molnupiravir and nirmatrelvir-ritonavir associated with improved outcomes among patients with type 2 diabetes and COVID-19? Findings In this cohort study of 22 098 patients in Hong Kong… read more here.
Keywords: cause; nirmatrelvir ritonavir; type diabetes; hospitalization ... See more keywords
Innovative Randomized Phase I Study and Dosing Regimen Selection to Accelerate and Inform Pivotal COVID‐19 Trial of Nirmatrelvir
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DOI: 10.1002/cpt.2603
Abstract: Coronavirus disease 2019 (COVID‐19) is a continued leading cause of hospitalization and death. Safe, efficacious COVID‐19 antivirals are needed urgently. Nirmatrelvir (PF‐07321332), the first orally bioavailable, severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2) Mpro inhibitor against… read more here.
Keywords: phase; pharmacology; dosing regimen; nirmatrelvir ritonavir ... See more keywords
Recommendations for the Management of Drug–Drug Interactions Between the COVID‐19 Antiviral Nirmatrelvir/Ritonavir (Paxlovid) and Comedications
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DOI: 10.1002/cpt.2646
Abstract: The coronavirus disease 2019 (COVID‐19) antiviral nirmatrelvir/ritonavir (Paxlovid) has been granted authorization or approval in several countries for the treatment of patients with mild to moderate COVID‐19 at high risk of progression to severe disease… read more here.
Keywords: nirmatrelvir ritonavir; risk; ritonavir; drug ... See more keywords
Physiologically‐Based Pharmacokinetic Modeling‐Guided Dose Management of Oral Anticoagulants when Initiating Nirmatrelvir/Ritonavir (Paxlovid) for COVID‐19 Treatment
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DOI: 10.1002/cpt.2687
Abstract: Patients with coronavirus disease 2019 (COVID‐19) with cardiovascular diseases who are at higher risk of progressing to critical illness should be treated with nirmatrelvir/ritonavir (Paxlovid). Ritonavir, the booster in nirmatrelvir/ritonavir, modulates multiple drug metabolizing enzymes… read more here.
Keywords: ritonavir paxlovid; based pharmacokinetic; nirmatrelvir ritonavir; physiologically based ... See more keywords
Pharmacokinetics of Oral Nirmatrelvir/Ritonavir, a Protease Inhibitor for Treatment of COVID‐19, in Subjects With Renal Impairment
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DOI: 10.1002/cpt.2688
Abstract: Nirmatrelvir coadministered with ritonavir is highly efficacious in reducing the risk of coronavirus disease 2019 (COVID‐19) adverse outcomes among patients at increased risk of progression to severe disease, including patients with chronic kidney disease. Because… read more here.
Keywords: impairment pharmacokinetics; nirmatrelvir ritonavir; impairment; renal impairment ... See more keywords
Nirmatrelvir–ritonavir might only be effective in elderly patients
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28418
Abstract: Nirmatrelvir-ritonavir is an effective and safe oral antiviral drug which have been shown to reduce the risk of progression to severe COVID-191 . It received emergency use authorization from the United States Food and Drug… read more here.
Keywords: elderly patients; nirmatrelvir ritonavir; ritonavir might; might effective ... See more keywords