TNFα-mediated activation of NF-κB downregulates sodium-iodide symporter expression in thyroid cells
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0228794
Abstract: The sodium-iodide symporter (NIS) mediates transport of iodide across the basolateral membrane of thyroid cells. NIS expression in thyroid cancer (TC) cells allows the use of radioactive iodine (RAI) as a diagnostic and therapeutic tool,… read more here.
Keywords: nis expression; expression; sodium iodide; iodide symporter ... See more keywords
Antagonistic effects of RAC1 and tumor-related RAC1b on NIS expression in thyroid.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular endocrinology"
DOI: 10.1530/jme-19-0195
Abstract: Thyroid cancer (TC) is the most common endocrine malignancy. The Sodium Iodide Symporter (NIS), responsible for active transport of iodide into thyroid cells, allows the use of radioactive iodine (RAI) as the systemic treatment of… read more here.
Keywords: expression; thyroid cells; rac1b; nis expression ... See more keywords
The master role of polarized NIS expression in regulating iodine metabolism in the human body.
Sign Up to like & getrecommendations! Published in 2023 at "Archives of endocrinology and metabolism"
DOI: 10.20945/2359-3997000000583
Abstract: Objective The aim of this study was to investigate how polarized sodium iodide symporter (NIS) expression may regulate iodide metabolism in vivo. Materials and methods Polarized NIS expression was analyzed in tissues that accumulate iodide… read more here.
Keywords: metabolism; nis expression; expression; polarized nis ... See more keywords
MiR-181a-5p Regulates NIS Expression in Papillary Thyroid Carcinoma
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DOI: 10.3390/ijms22116067
Abstract: NIS is a potent iodide transporter encoded by the SLC5A5 gene. Its expression is reduced in papillary thyroid carcinoma (PTC). In this study we analyzed the impact of miR-181a-5p on NIS expression in the context… read more here.
Keywords: papillary thyroid; slc5a5; thyroid carcinoma; expression ... See more keywords