Navigating the Unnatural Reaction Space: Directed Evolution of Heme Proteins for Selective Carbene and Nitrene Transfer.
Sign Up to like & getrecommendations! Published in 2021 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.0c00591
Abstract: ConspectusDespite the astonishing diversity of naturally occurring biocatalytic processes, enzymes do not catalyze many of the transformations favored by synthetic chemists. Either nature does not care about the specific products, or if she does, she… read more here.
Keywords: heme proteins; carbene nitrene; carbene; nitrene transfer ... See more keywords
Origin of the Distinctive Electronic Structure of Co- and Fe-Porphyrin-Nitrene and Its Effect on Their Nitrene Transfer Reactivity.
Sign Up to like & getrecommendations! Published in 2023 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.3c00463
Abstract: Metal-bound nitrene species are the crucial intermediate in catalytic nitrene transfer reactions exhibited by engineered enzymes and molecular catalysts. The electronic structure of such species and its correlation with nitrene transfer reactivity have not been… read more here.
Keywords: porphyrin nitrene; nitrene; nitrene transfer; electronic structure ... See more keywords
Iron(II)-Catalyzed Nitrene Transfer Reaction of Sulfoxides with N-Acyloxyamides.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01990
Abstract: An iron(II)-catalyzed nitrene transfer reaction of sulfoxides with N-acyloxyamides has been developed, leading to the efficient construction of N-acyl sulfoximines with high functional-group compatibility. The current catalytic transformation was carried out under an air atmosphere… read more here.
Keywords: nitrene transfer; catalyzed nitrene; transfer reaction; reaction sulfoxides ... See more keywords
Rh(II)-Catalyzed Nitrene-Transfer [5 + 1] Cycloadditions of Aryl-Substituted Vinylcyclopropanes.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b00594
Abstract: Formal [5 + 1] cycloadditions between aryl-substituted vinylcyclopropanes and nitrenoid precursors are reported. The method, which employs Rh2(esp)2 as a catalyst, leads to the highly regioselective formation of substituted tetrahydropyridines. Preliminary mechanistic studies support a… read more here.
Keywords: aryl substituted; nitrene transfer; cycloadditions aryl; catalyzed nitrene ... See more keywords
Regioselective differentiation of vicinal methylene C-H bonds enabled by silver-catalysed nitrene transfer.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc04006d
Abstract: Silver-catalyzed nitrene insertion enables the formation of benzosultams in good yield and with regioselectivity complementary to other transition metal nitrene-transfer catalysts. Preferential formation of six-membered benzosultam rings predominates for alkyl-substituted benzenesulphonamide precursors. Ligand-controlled tunability is… read more here.
Keywords: differentiation vicinal; vicinal methylene; nitrene transfer; nitrene ... See more keywords
Transition metal-catalysed carbene- and nitrene transfer to carbon monoxide and isocyanides
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Society Reviews"
DOI: 10.1039/d1cs00305d
Abstract: Transition metal-catalysed carbene- and nitrene transfer to the C1-building blocks carbon monoxide and isocyanides provides heteroallenes (i.e. ketenes, isocyanates, ketenimines and carbodiimides). These are versatile and reactive compounds allowing in situ transformation towards numerous functional… read more here.
Keywords: catalysed carbene; transition metal; nitrene transfer; carbene nitrene ... See more keywords
Nitrene transfer reaction with hydroxylamine derivatives.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d2cc06318b
Abstract: Recent progress on catalytic nitrene transfer reactions with hydroxylamine derivatives as prevalent precursors is summarized in this highlight. The salient features of these N-O derived nitrene transfer reagents are that they are readily available, bench-stable,… read more here.
Keywords: transfer reaction; hydroxylamine derivatives; reaction hydroxylamine; nitrene transfer ... See more keywords