Ni-Catalyzed Regioselective Alkylarylation of Unactivated Alkenes in Amines Enabled by Cooperative Ligand Effects of Nitriles and Electron-Deficient Alkenes.
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DOI: 10.1021/jacs.4c12334
Abstract: We report a Ni-catalyzed vicinal alkylarylation of unactivated alkenes in γ,δ- and δ,ε-alkenylamines with aryl halides and alkylzinc reagents. The reaction is enabled by amine coordination and can use all primary, secondary, and tertiary amines.… read more here.
Keywords: unactivated alkenes; nitriles electron; electron deficient; enabled cooperative ... See more keywords