Odd Loop Regions of XenA and XenB Enzymes Modulate Their Interaction with Nitro-explosives Compounds and Provide Structural Support for Their Regioselectivity
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DOI: 10.1021/acs.jcim.9b00357
Abstract: The nitro-explosive compounds 2,4,6-trinitrotoluene, 2,4,6-trinitrophenol and 1,2,3- trinitroglycerol are persistent environmental contaminants. The presence of different functional groups in these molecules represents a great challenge to enzymatic catalysis. The chemical variety of these three substrates… read more here.
Keywords: reductase; regioselectivity; nitro; interaction ... See more keywords
Organocatalytic Enantioselective Nitro-Vinylcyclopropane-Cyclopentene Rearrangement: Expanding the Reactivity of Donor–Acceptor Cyclopropanes
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DOI: 10.1055/a-2640-6415
Abstract: The catalytic enantioselective rearrangement of nitro-vinylcyclopropylacetaldehydes has been studied using chiral secondary amines as catalysts. The reaction proceeds through the in situ generation of a donor–acceptor cyclopropane, which rearranges to the corresponding cyclopentene through an… read more here.
Keywords: rearrangement; cyclopentene; nitro; donor acceptor ... See more keywords