Recyclable Chiral Bifunctional Thioureas Derived from [60]Fullerene and Their Use as Highly Efficient Organocatalysts for the Asymmetric Nitro-Michael Reaction
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DOI: 10.1002/ejoc.201601640
Abstract: Three novel fullerothioureas derived from natural valine, phenylalanine, and tert-leucine have been prepared by Prato's reaction of [60]fullerene and the corresponding aldehydes. These hybrids have been used as organocatalysts in a typical stereoselective nitro-Michael addition… read more here.
Keywords: nitro michael; recyclable chiral; chiral bifunctional; bifunctional thioureas ... See more keywords
A Sequential Nitro‐Michael Addition and Reductive Cyclization Cascade Reaction for Diastereoselective Synthesis of Multifunctionalized 3,3'‐pyrrolidinyl‐spirooxindoles
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DOI: 10.1002/ejoc.202401121
Abstract: In this investigation, we elucidated, one‐pot two stage efficient synthesis of multifuctionalized spiro[oxindole ‐3,3′‐pyrrolidine]. The methodology proceeds via organocatalyzed nitro‐Michael addition reaction between indolylidenecyanoesters and nitroalkanes to formed nitro‐Michael adduct which transformed into multifunctionalized 3,3'‐pyrrolidinyl‐spirooxindoles… read more here.
Keywords: reaction; michael addition; pyrrolidinyl spirooxindoles; multifunctionalized pyrrolidinyl ... See more keywords