Nitro-oleic acid regulates differentiation of embryonic stem cells
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.10.095
Abstract: Nitro-fatty acids (NO2-FA) are pluripotent signaling molecules endogenously generated as an adaptive response of organism to oxidative and nitrative stress. Recently, we have discovered some new aspects of NO2-FA functions in regulation of stem cell… read more here.
Keywords: nitro oleic; embryonic stem; oleic acid; differentiation ... See more keywords
Nitro-oleic acid, a ligand of CD36, reduces cholesterol accumulation by modulating oxidized-LDL uptake and cholesterol efflux in RAW264.7 macrophages
Sign Up to like & getrecommendations! Published in 2020 at "Redox Biology"
DOI: 10.1016/j.redox.2020.101591
Abstract: Macrophages play a pivotal role in the early stages of atherosclerosis development; they excessively accumulate cholesterol in the cytosol in response to modified Low Density Lipoprotein (mLDL). The mLDL are incorporated through scavenger receptors. CD36… read more here.
Keywords: reduces cholesterol; raw264 macrophages; nitro oleic; oleic acid ... See more keywords
Evaluation of 10-Nitro Oleic Acid Bio-Elimination in Rats and Humans
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep39900
Abstract: Nitrated fatty acids are endogenously present in human and animal tissues, as well as in plant-derived oils. In particular, 10-nitro oleic acid (10-NO2-OA) potently induces Nrf2-dependent antioxidant gene expression and inhibits TLR4/NF-κB signaling, thus promoting… read more here.
Keywords: rats humans; nitro oleic; oleic acid; bio elimination ... See more keywords
Nitro-oleic acid regulates T cell activation through post-translational modification of calcineurin.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2208924120
Abstract: Nitro-fatty acids (NO2-FAs) are unsaturated fatty acid nitration products that exhibit anti-inflammatory actions in experimental mouse models of autoimmune and allergic diseases. These electrophilic molecules interfere with intracellular signaling pathways by reversible post-translational modification of… read more here.
Keywords: post translational; nitro oleic; acid; translational modification ... See more keywords
Nitro-oleic acid (NO2-OA) reduces thoracic aortic aneurysm progression in a mouse model of Marfan syndrome.
Sign Up to like & getrecommendations! Published in 2021 at "Cardiovascular research"
DOI: 10.1093/cvr/cvab256
Abstract: AIMS Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in the Fibrillin-1 gene. It is associated with formation of thoracic aortic aneurysms that can potentially be a life-threatening condition due to aortic… read more here.
Keywords: nitro oleic; marfan syndrome; oleic acid; thoracic aortic ... See more keywords
Exogenous Nitro-Oleic Acid Treatment Inhibits Primary Root Growth by Reducing the Mitosis in the Meristem in Arabidopsis thaliana
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2020.01059
Abstract: Nitric oxide (NO) is a second messenger that regulates a broad range of physiological processes in plants. NO-derived molecules called reactive nitrogen species (RNS) can react with unsaturated fatty acids generating nitrated fatty acids (NO2-FA).… read more here.
Keywords: nitro oleic; root; root growth; oleic acid ... See more keywords
Nitro-Oleic Acid in Seeds and Differently Developed Seedlings of Brassica napus L.
Sign Up to like & getrecommendations! Published in 2020 at "Plants"
DOI: 10.3390/plants9030406
Abstract: Similar to animals, it has recently been proven that nitro-fatty acids such as nitro-linolenic acid and nitro-oleic acid (NO2-OA) have relevant physiological roles as signalling molecules also in plants. Although NO2-OA is of great therapeutic… read more here.
Keywords: brassica; nitro oleic; oleic acid; brassica napus ... See more keywords