A Nitroalkene Benzoic Acid Derivative Targets Reactive Microglia and Prolongs Survival in an Inherited Model of ALS via NF-κB Inhibition
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DOI: 10.1007/s13311-020-00953-z
Abstract: Motor neuron degeneration and neuroinflammation are the most striking pathological features of amyotrophic lateral sclerosis (ALS). ALS currently has no cure and approved drugs have only a modest clinically therapeutic effect in patients. Drugs targeting… read more here.
Keywords: acid derivative; inhibition; benzoic acid; motor ... See more keywords