Intra-amniotic Sildenafil Treatment Modulates Vascular Smooth Muscle Cell Phenotype in the Nitrofen Model of Congenital Diaphragmatic Hernia
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DOI: 10.1038/s41598-018-34948-w
Abstract: The etiology of pulmonary vascular abnormalities in CDH is incompletely understood. Studies have demonstrated improvement in pulmonary vasculature with prenatal therapy in animal models. We hypothesize that prenatal sildenafil may attenuate defective pulmonary vascular development… read more here.
Keywords: phenotype; vsmc phenotype; nitrofen model; sildenafil ... See more keywords