Nitrogen Mustard Alkylates and Cross-Links p53 in Human Keratinocytes.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.1c00420
Abstract: Cytotoxic blistering agents such as sulfur mustard and nitrogen mustard (HN2) were synthesized for chemical warfare. Toxicity is due to reactive chloroethyl side chains that modify and damage cellular macromolecules including DNA and proteins. In… read more here.
Keywords: cross links; dna; cross linked; nitrogen mustard ... See more keywords
Sensing Nitrogen Mustard Gas Simulant at the ppb Scale via Selective Dual-Site Activation at Au/Mn3O4 Interfaces.
Sign Up to like & getrecommendations! Published in 2019 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.9b04875
Abstract: The efficient detection of chemical warfare agents (CWAs), putting at stake human life and global safety, is of paramount importance in the development of reliable sensing devices for safety applications. Herein, we present the fabrication… read more here.
Keywords: simulant; detection; gas; nitrogen mustard ... See more keywords
Rational design and characterization of a DNA/HDAC dual-targeting inhibitor containing nitrogen mustard and 2-aminobenzamide moieties.
Sign Up to like & getrecommendations! Published in 2018 at "MedChemComm"
DOI: 10.1039/c7md00476a
Abstract: Histone deacetylases (HDACs) play a key role not only in gene expression but also in DNA repair. Herein, we report the rational design and characterization of a compound named chlordinaline containing nitrogen mustard and 2-aminobenzamide… read more here.
Keywords: mustard aminobenzamide; dual targeting; dna hdac; nitrogen mustard ... See more keywords
‘Is nitrogen mustard contamination responsible for the reported MT‐45 toxicity?’ Reply from the authors
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Dermatology"
DOI: 10.1111/bjd.15676
Abstract: appear to contain any major organic impurities; however, as different distributors likely obtain this substance from distinct sources or manufacturers, it seems possible that only some batches would be contaminated. The analysis of blood samples… read more here.
Keywords: reported toxicity; toxicity reply; contamination responsible; nitrogen mustard ... See more keywords
MG53 attenuates nitrogen mustard‐induced acute lung injury
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16917
Abstract: Nitrogen mustard (NM) is an alkylating vesicant that causes severe pulmonary injury. Currently, there are no effective means to counteract vesicant‐induced lung injury. MG53 is a vital component of cell membrane repair and lung protection.… read more here.
Keywords: nitrogen mustard; lung injury; mg53; induced lung ... See more keywords
3D- and 2D-QSAR models’ study and molecular docking of novel nitrogen-mustard compounds for osteosarcoma
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2023.1164349
Abstract: Background: The dipeptide-alkylated nitrogen-mustard compound is a new kind of nitrogen-mustard derivative with a strong anti-tumor activity, which can be used as a potential anti-osteosarcoma chemotherapy drug. Objective: 2D- and 3D-QSAR (structure–activity relationship quantification) models… read more here.
Keywords: mustard compounds; nitrogen mustard; dipeptide alkylated; activity ... See more keywords
Melatonin as Modulator for Sulfur and Nitrogen Mustard-Induced Inflammation, Oxidative Stress and DNA Damage: Molecular Therapeutics
Sign Up to like & getrecommendations! Published in 2023 at "Antioxidants"
DOI: 10.3390/antiox12020397
Abstract: Sulfur and nitrogen mustards, bis(2-chloroethyl)sulfide and tertiary bis(2-chloroethyl) amines, respectively, are vesicant warfare agents with alkylating activity. Moreover, oxidative/nitrosative stress, inflammatory response induction, metalloproteinases activation, DNA damage or calcium disruption are some of the toxicological… read more here.
Keywords: sulfur nitrogen; mustard induced; damage; nitrogen mustard ... See more keywords