Imidazole and nitroimidazole derivatives as NADH‐fumarate reductase inhibitors: Density functional theory studies, homology modeling, and molecular docking
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DOI: 10.1002/jcc.26959
Abstract: Chagas disease is caused by Trypanosoma cruzi. Benznidazole and nifurtimox are drugs used for its therapy; nevertheless, they have collateral effects. NADH‐fumarate (FUM) reductase is a potential pharmacological target since it is essential for survival… read more here.
Keywords: fum reductase; nadh fum; nitroimidazole derivatives; imidazole nitroimidazole ... See more keywords
Novel nitroimidazole derivatives evaluated for their trypanocidal, cytotoxic, and genotoxic activities.
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DOI: 10.1016/j.ejmech.2019.111887
Abstract: The current treatment of Chagas disease is based on the use of two drugs, nifurtimox (Nfx) and benznidazole (Bnz), both of which present limited efficacy in the chronic stage of the disease and toxic side… read more here.
Keywords: nitroimidazole derivatives; genotoxic activities; derivatives evaluated; novel nitroimidazole ... See more keywords
Near-infrared fluorescence probe: BSA-protected gold nanoclusters for the detection of metronidazole and related nitroimidazole derivatives
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DOI: 10.1039/c6ay03280j
Abstract: In this work, a novel near-infrared fluorescence probe based on BSA-protected gold nanoclusters (AuNCs@BSA) is designed for the detection of metronidazole (MTZ) and nitroimidazole derivatives. Compared with other wavelengths for fluorescence probes, near-infrared light for… read more here.
Keywords: fluorescence; nitroimidazole derivatives; bsa; near infrared ... See more keywords