Quantum chemical investigation of the formation of spiroheterocyclic compounds via the (3 + 2) cycloaddition reaction of 1-methyl-3-(2,2,2-trifluoroethylidene) pyrrolidin-2-one with diazomethane and nitrone derivatives
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DOI: 10.1016/j.tet.2021.132306
Abstract: Abstract The chemo-, regio- and stereoselectivities of the formation of spiroheterocycles via the (3 + 2) cycloaddition (32CA) reaction of 1-methyl-3-(2,2,2-trifluoroethylidene) pyrrolidin-2-one (A1) derivatives with diazomethane and nitrone derivative have been studied at the M06–2X/6-311G level of… read more here.
Keywords: trifluoroethylidene pyrrolidin; reaction methyl; pyrrolidin one; nitrone ... See more keywords
Semi-synthesis of a novel hybrid isoxazolidino withaferin via chemoselective and diastereoselective 1,3-dipolar nitrone cycloaddition reaction
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DOI: 10.1080/14786419.2019.1582045
Abstract: Abstract A facile, atom-economic synthesis of isoxazilidino withaferin, a novel hybrid of withaferin A, has been accomplished via two-step reaction of nitrone synthesis followed by nitrone 1,3-dipolar cycloaddition. The reaction is highly chemoselective (preferential reaction… read more here.
Keywords: withaferin; nitrone; reaction; cycloaddition reaction ... See more keywords