Bridged-Type Selective Intramolecular Nitrone-Alkene Cycloaddition: Computational Chemistry-Inspired Regioselectivity Control.
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DOI: 10.1021/acs.orglett.5c00125
Abstract: A regioselective intramolecular nitrone-alkene cycloaddition for synthesizing oxazabicyclo ring-fused indoles is reported. Computational studies guided the development of optimal conditions using In(OTf)3 as a Lewis acidic reagent. This method demonstrates a broad substrate scope, forming… read more here.
Keywords: intramolecular nitrone; chemistry; alkene cycloaddition; nitrone alkene ... See more keywords