Copper-Catalyzed Synthesis of Polysubstituted Pyrroles through [3+1+1] Cycloaddition Reaction of Nitrones and Isocyanides.
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DOI: 10.1021/acs.orglett.8b00798
Abstract: An efficient, copper-catalyzed [3+1+1] cycloaddition reaction was developed for the expedient synthesis of pharmacologically interesting polysubstituted pyrroles from easily available nitrones and α-acidic isocyanides. The given approach features a new mode of cycloaddition between nitrones… read more here.
Keywords: polysubstituted pyrroles; nitrones isocyanides; cycloaddition; reaction ... See more keywords