New Biocompatible β‐Phosphorylated Linear Nitrones Targeting Mitochondria: Protective Effect in Apoptotic Cells
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DOI: 10.1002/cbic.202200749
Abstract: The mitochondrion, an essential organelle involved in cellular respiration, energy production, and cell death, is the main cellular source of reactive oxygen species (ROS), including superoxide. Mitochondrial diseases resulting from uncontrolled/excess ROS generation are an… read more here.
Keywords: new biocompatible; biocompatible phosphorylated; targeting mitochondria; phosphorylated linear ... See more keywords
Aziridination of Cyclic Nitrones Targeting Constrained Iminosugars.
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DOI: 10.1021/acs.orglett.7b02283
Abstract: Rare C-7-substituted aziridinyl iminosugars can be synthesized through a short reaction sequence involving 1,3-cycloaddition of cyclic nitrones with alkynes and a Baldwin rearrangement of isoxazolines into bicyclic 2-acylaziridines. The method is efficient and completely diastereoselective,… read more here.
Keywords: constrained iminosugars; nitrones targeting; cyclic nitrones; targeting constrained ... See more keywords