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Published in 2023 at "ChemBioChem"
DOI: 10.1002/cbic.202200749
Abstract: The mitochondrion, an essential organelle involved in cellular respiration, energy production, and cell death, is the main cellular source of reactive oxygen species (ROS), including superoxide. Mitochondrial diseases resulting from uncontrolled/excess ROS generation are an…
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Keywords:
new biocompatible;
biocompatible phosphorylated;
targeting mitochondria;
phosphorylated linear ... See more keywords
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Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.7b02283
Abstract: Rare C-7-substituted aziridinyl iminosugars can be synthesized through a short reaction sequence involving 1,3-cycloaddition of cyclic nitrones with alkynes and a Baldwin rearrangement of isoxazolines into bicyclic 2-acylaziridines. The method is efficient and completely diastereoselective,…
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Keywords:
constrained iminosugars;
nitrones targeting;
cyclic nitrones;
targeting constrained ... See more keywords