A pioneer study on human 3‐nitropropionic acid intoxication: Contributions from metabolomics
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4259
Abstract: The neurotoxin 3‐nitropropionic acid (3‐NPA) is an inhibitor of succinate dehydrogenase, an enzyme participating both in the citric acid cycle and the mitochondrial respiratory chain. In human intoxications, it produces symptoms such as vomiting and… read more here.
Keywords: intoxication; pioneer study; study human; nitropropionic acid ... See more keywords
Nicotinamide reverses behavioral impairments and provides neuroprotection in 3˗nitropropionic acid induced animal model ofHuntington’s disease: implication of oxidative stress˗ poly(ADP˗ ribose) polymerase pathway
Sign Up to like & getrecommendations! Published in 2018 at "Metabolic Brain Disease"
DOI: 10.1007/s11011-018-0297-0
Abstract: Huntington’s disease (HD) is characterized by cognitive and psychiatric impairment caused by neuronal degeneration in the brain. Several studies have supported the hypothesis that oxidative stress is the main pathogenic factor in HD. The current… read more here.
Keywords: acid induced; disease; nitropropionic acid; stress ... See more keywords
Sodium selenite protects from 3-nitropropionic acid-induced oxidative stress in cultured primary cortical neurons
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Biology Reports"
DOI: 10.1007/s11033-018-4531-y
Abstract: Selenium (Se) is an essential trace element for humans; its intake is needed to allow the proper synthesis of 25 different selenoproteins that are necessary to the normal functioning of several organs, including the brain.… read more here.
Keywords: acid induced; induced oxidative; sodium; nitropropionic acid ... See more keywords
Anti-Huntington’s Effect of Butin in 3-Nitropropionic Acid-Treated Rats: Possible Mechanism of Action
Sign Up to like & getrecommendations! Published in 2022 at "Neurotoxicity Research"
DOI: 10.1007/s12640-021-00462-7
Abstract: Butin has a strong antioxidant plus anti-inflammatory action and it is reported to be protective in oxidative stress-induced mitochondrial dysfunction. Butin has been shown to protect the mouse hippocampus HT22 cells from glutamate-induced neurotoxicity. The… read more here.
Keywords: butin nitropropionic; anti huntington; nitropropionic acid; huntington effect ... See more keywords
Telmisartan neuroprotective effects in 3-nitropropionic acid Huntington's disease model in rats: Cross talk between PPAR-γ and PI3K/Akt/GSK-3β pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Life sciences"
DOI: 10.1016/j.lfs.2022.120480
Abstract: Huntington's disease (HD) is an inherited devastating neurodegenerative disorder with disabling motor and cognitive derangements that hinder the patients from performing their daily activities. AIMS The present study was carried out to investigate telmisartan-induced neuroprotection… read more here.
Keywords: akt gsk; huntington disease; neuroprotective effects; model rats ... See more keywords
Comparison of quantitative T2 and ADC mapping in the assessment of 3‐nitropropionic acid‐induced neurotoxicity in rats
Sign Up to like & getrecommendations! Published in 2018 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2018.02.004
Abstract: ABSTRACT To assess the relative performance of MRI T2 relaxation and ADC mapping as potential biomarkers of neurotoxicity, a model of 3‐nitropropionic acid (NP)‐induced neurodegeneration in rats was employed. Male Sprague‐Dawley rats received NP (N… read more here.
Keywords: adc mapping; adc; acid induced; nitropropionic acid ... See more keywords
Ameliorating effect of Celastrus paniculatus standardized extract and its fractions on 3-nitropropionic acid induced neuronal damage in rats: possible antioxidant mechanism
Sign Up to like & getrecommendations! Published in 2017 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2017.1285945
Abstract: Abstract Context: Celastrus paniculatus Wild. (Celasteraceae) (CP) is a well-known Ayurvedic ‘Medhya Rasayana’ (nervine tonic), used extensively as a neuro-protective and memory enhancer, and in different central nervous system disorders. Objective: To evaluate the effect… read more here.
Keywords: acid induced; effect; celastrus paniculatus; nitropropionic acid ... See more keywords
Oral administration of hydroalcoholic extract of Centella asiatica ameliorates neurotoxicity and neurobehavioral deficits in 3-nitropropionic acid-induced Huntington's like symptoms in adult zebrafish.
Sign Up to like & getrecommendations! Published in 2022 at "Rejuvenation research"
DOI: 10.1089/rej.2022.0036
Abstract: BACKGROUND Huntington's disease is an inherited neurodegenerative disease. 3- nitropropionic acid (3-NP) causes increased ROS production and neuroinflammation. Centella asiatica (CA) is a strong antioxidant. AIM To investigate the effect of hydroalcoholic extract of Centella… read more here.
Keywords: adult zebrafish; centella asiatica; administration; nitropropionic acid ... See more keywords
Pradoshia eiseniae gen. nov., sp. nov., a spore-forming member of the family Bacillaceae capable of assimilating 3-nitropropionic acid, isolated from the anterior gut of the earthworm Eisenia fetida.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of systematic and evolutionary microbiology"
DOI: 10.1099/ijsem.0.003304
Abstract: A Gram-stain-positive, spore-forming bacterium, EAG3T, capable of growing on 3-nitropropionic acid as the sole source of carbon, nitrogen and energy, was isolated from the anterior gut of an earthworm (Eisenia fetida) reared at the Centre… read more here.
Keywords: nitropropionic acid; isolated anterior; strain eag3t; strain ... See more keywords
In vivo longitudinal visualization of the brain neuroinflammatory response at the cellular level in LysM-GFP mice induced by 3-nitropropionic acid.
Sign Up to like & getrecommendations! Published in 2020 at "Biomedical optics express"
DOI: 10.1364/boe.393690
Abstract: Blood-brain barrier (BBB) dysfunction is related to the development of neuroinflammation in the central nervous system (CNS). Neuroinflammation has been implicated as one of the key factors in the pathogenesis of neurodegenerative diseases such as… read more here.
Keywords: lysm gfp; gfp; nitropropionic acid; brain ... See more keywords
Endophytic fungus Phomopsis sp. as a source of 3-nitropropionic acid with larvicidal activity against Aedes aegypti (Linnaeus 1762, Diptera: Culicidae)
Sign Up to like & getrecommendations! Published in 2022 at "Revista da Sociedade Brasileira de Medicina Tropical"
DOI: 10.1590/0037-8682-0018-2022
Abstract: ABSTRACT Background: Aedes aegypti is the primary vector of viruses, such as Zika, chikungunya, yellow fever, and dengue. In this context, a biomonitored chemical study was conducted to evaluate the activity of the crude extract… read more here.
Keywords: aedes aegypti; nitropropionic acid; endophytic fungus; activity ... See more keywords