Role of Human Aldo-Keto Reductases and Nuclear Factor Erythroid 2-Related Factor 2 in the Metabolic Activation of 1-Nitropyrene via Nitroreduction in Human Lung Cells.
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DOI: 10.1021/acs.chemrestox.2c00337
Abstract: 1-Nitropyrene (1-NP) is a constituent of diesel exhaust and classified as a group 2A probable human carcinogen. The metabolic activation of 1-NP by nitroreduction generates electrophiles that can covalently bind DNA to form mutations to… read more here.
Keywords: metabolic activation; keto reductases; factor; nitroreduction ... See more keywords