Practical and Science-Based Strategy for Establishing Acceptable Intakes for Drug Product N-Nitrosamine Impurities
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Research in Toxicology"
DOI: 10.1021/acs.chemrestox.1c00369
Abstract: The potential for N-nitrosamine impurities in pharmaceutical products presents a challenge for the quality management of medicinal products. N-Nitrosamines are considered cohort-of-concern compounds due to the potent carcinogenicity of many of the structurally simple chemicals… read more here.
Keywords: nitrosamine; drug product; practical science; nitrosamine impurities ... See more keywords
The Protective Effect of Curcumin against Nitrosamine-Induced Gastric Oxidative Stress in Rats
Sign Up to like & getrecommendations! Published in 2018 at "Preventive Nutrition and Food Science"
DOI: 10.3746/pnf.2018.23.4.288
Abstract: Curcumin has a wide spectrum of biological, pharmaceutical, and antioxidant effects in cancer experimental models. Nitrosamine is commonly used as an experimental oxidizing agent which induces gastric oxidative stress and gastric carcinogenesis in rats. We… read more here.
Keywords: nitrosamine; effect; stress; gastric oxidative ... See more keywords