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   Articles with "nitrosation" as a keyword



A guanylyl cyclase-thioredoxin transnitrosation complex

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recommendations! Published in 2018 at "Free Radical Biology and Medicine"

DOI: 10.1016/j.freeradbiomed.2018.10.030

Abstract: Nitric Oxide (NO) is best known for its ability to stimulate soluble guanylyl cyclase (sGC) to produce cGMP and stimulate its downstream signaling pathways. However, NO can also covalently modify cysteines via S-nitrosation (addition of… read more here.

Keywords: protein; transnitrosation; thioredoxin; guanylyl cyclase ... See more keywords

SOCS1 S-Nitrosation in the nucleus is a switch of macrophage polarization and function

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recommendations! Published in 2018 at "Free Radical Biology and Medicine"

DOI: 10.1016/j.freeradbiomed.2018.10.239

Abstract: Macrophages play a critical role in inflammation initiation, progression and resolution due to their capacity to assume both pro- and anti-inflammatory phenotypes. The molecular mechanisms that regulate these transitions are of great clinical interest but… read more here.

Keywords: p50; nitrosation nucleus; macrophage polarization; inflammatory ... See more keywords

L‐&bgr;‐N‐methylamino‐L‐alanine (BMAA) nitrosation generates a cytotoxic DNA damaging alkylating agent: An unexplored mechanism for neurodegenerative disease

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recommendations! Published in 2017 at "Neurotoxicology"

DOI: 10.1016/j.neuro.2017.01.007

Abstract: Background: L‐&bgr;‐N‐methylamino‐L‐alanine (BMAA) is a non‐proteinic amino acid, that is neurotoxic in vitro and in animals, and is implicated in the causation of amyotrophic lateral sclerosis and parkinsonism‐dementia complex (ALS‐PDC) on Guam. Given that natural… read more here.

Keywords: alanine bmaa; alkylating agent; bgr methylamino; bmaa ... See more keywords

S-nitrosation impairs KLF4 activity and instigates endothelial dysfunction in pulmonary arterial hypertension

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recommendations! Published in 2019 at "Redox Biology"

DOI: 10.1016/j.redox.2019.101099

Abstract: Krüppel-like factor 4 (KLF4) is a transcription factor with conserved zinc finger domains. As an essential regulator of vascular homeostasis, KLF4 exerts a protective effect in endothelial cells (ECs), including regulating vasodilation, inflammation, coagulation and… read more here.

Keywords: klf4; arterial hypertension; pulmonary arterial; nitrosation ... See more keywords
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Downregulation of thioredoxin-1-dependent CD95 S-nitrosation by Sorafenib reduces liver cancer

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recommendations! Published in 2020 at "Redox Biology"

DOI: 10.1016/j.redox.2020.101528

Abstract: Hepatocellular carcinoma (HCC) represents 80% of the primary hepatic neoplasms. It is the sixth most frequent neoplasm, the fourth cause of cancer-related death, and 7% of registered malignancies. Sorafenib is the first line molecular targeted… read more here.

Keywords: thioredoxin; downregulation; cancer; nitrosation ... See more keywords

An efficient process for the synthesis of gem-dinitro compounds under high steric hindrance by nitrosation and oxidation of secondary nitroalkanes

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recommendations! Published in 2018 at "Tetrahedron Letters"

DOI: 10.1016/j.tetlet.2018.05.002

Abstract: Abstract A new nitrosation and oxidation process to synthesize gem -dinitro compounds was accomplished by using nitryl chloride as nitrosation reagent and ozone as oxidizing agent. The main features of the present protocol include the… read more here.

Keywords: gem; dinitro compounds; nitrosation oxidation; high steric ... See more keywords

Role of Carbonyl Compounds for N-Nitrosamine Formation during Nitrosation: Kinetics and Mechanisms

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recommendations! Published in 2024 at "Environmental Science & Technology"

DOI: 10.1021/acs.est.3c07461

Abstract: N-Nitrosamines are potential human carcinogens frequently detected in natural and engineered aquatic systems. This study sheds light on the role of carbonyl compounds in the formation of N-nitrosamines by nitrosation of five secondary amines via… read more here.

Keywords: role carbonyl; nitrosamine formation; nitrosation; carbonyl compounds ... See more keywords

N-Nitrosation Mechanism Catalyzed by Non-heme Iron-Containing Enzyme SznF Involving Intramolecular Oxidative Rearrangement.

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recommendations! Published in 2021 at "Inorganic chemistry"

DOI: 10.1021/acs.inorgchem.1c00057

Abstract: The non-heme iron-dependent enzyme SznF catalyzes a critical N-nitrosation step during the N-nitrosourea pharmacophore biosynthesis in streptozotocin. The intramolecular oxidative rearrangement process is known to proceed at the FeII-containing active site in the cupin domain… read more here.

Keywords: mechanism; nitrosation; sznf; heme iron ... See more keywords

Warhead Strategy for Targeted Protein S-Nitrosation.

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recommendations! Published in 2025 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.5c07409

Abstract: Protein post-translational modifications (PTMs) are critical factors in disease progression. While progress has been made in regulating disease-associated PTMs such as phosphorylation and acetylation, the approach to achieving targeted S-nitrosation for disease treatment, particularly in… read more here.

Keywords: targeted nitrosation; targeted protein; strategy targeted; nitrosation ... See more keywords

S-Nitrosation of E3 Ubiquitin Ligase Complex Components Regulates Hormonal Signalings in Arabidopsis

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recommendations! Published in 2022 at "Frontiers in Plant Science"

DOI: 10.3389/fpls.2021.794582

Abstract: E3 ubiquitin ligases mediate the last step of the ubiquitination pathway in the ubiquitin-proteasome system (UPS). By targeting transcriptional regulators for their turnover, E3s play a crucial role in every aspect of plant biology. In… read more here.

Keywords: ligase complex; ubiquitin ligase; nitrosation ubiquitin; nitrosation ... See more keywords

Proteomic Analysis of S-Nitrosation Sites During Somatic Embryogenesis in Brazilian Pine, Araucaria angustifolia (Bertol.) Kuntze

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recommendations! Published in 2022 at "Frontiers in Plant Science"

DOI: 10.3389/fpls.2022.902068

Abstract: Cysteine S-nitrosation is a redox-based post-translational modification that mediates nitric oxide (NO) regulation of various aspects of plant growth, development and stress responses. Despite its importance, studies exploring protein signaling pathways that are regulated by… read more here.

Keywords: embryogenesis; brazilian pine; somatic embryogenesis; embryogenesis brazilian ... See more keywords