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   Articles with "nitrosation" as a keyword



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A guanylyl cyclase-thioredoxin transnitrosation complex

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recommendations! Published in 2018 at "Free Radical Biology and Medicine"

DOI: 10.1016/j.freeradbiomed.2018.10.030

Abstract: Nitric Oxide (NO) is best known for its ability to stimulate soluble guanylyl cyclase (sGC) to produce cGMP and stimulate its downstream signaling pathways. However, NO can also covalently modify cysteines via S-nitrosation (addition of… read more here.

Keywords: protein; transnitrosation; thioredoxin; guanylyl cyclase ... See more keywords
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SOCS1 S-Nitrosation in the nucleus is a switch of macrophage polarization and function

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recommendations! Published in 2018 at "Free Radical Biology and Medicine"

DOI: 10.1016/j.freeradbiomed.2018.10.239

Abstract: Macrophages play a critical role in inflammation initiation, progression and resolution due to their capacity to assume both pro- and anti-inflammatory phenotypes. The molecular mechanisms that regulate these transitions are of great clinical interest but… read more here.

Keywords: p50; nitrosation nucleus; macrophage polarization; inflammatory ... See more keywords
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L‐&bgr;‐N‐methylamino‐L‐alanine (BMAA) nitrosation generates a cytotoxic DNA damaging alkylating agent: An unexplored mechanism for neurodegenerative disease

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recommendations! Published in 2017 at "Neurotoxicology"

DOI: 10.1016/j.neuro.2017.01.007

Abstract: Background: L‐&bgr;‐N‐methylamino‐L‐alanine (BMAA) is a non‐proteinic amino acid, that is neurotoxic in vitro and in animals, and is implicated in the causation of amyotrophic lateral sclerosis and parkinsonism‐dementia complex (ALS‐PDC) on Guam. Given that natural… read more here.

Keywords: alanine bmaa; alkylating agent; bgr methylamino; bmaa ... See more keywords
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S-nitrosation impairs KLF4 activity and instigates endothelial dysfunction in pulmonary arterial hypertension

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recommendations! Published in 2019 at "Redox Biology"

DOI: 10.1016/j.redox.2019.101099

Abstract: Krüppel-like factor 4 (KLF4) is a transcription factor with conserved zinc finger domains. As an essential regulator of vascular homeostasis, KLF4 exerts a protective effect in endothelial cells (ECs), including regulating vasodilation, inflammation, coagulation and… read more here.

Keywords: klf4; arterial hypertension; pulmonary arterial; nitrosation ... See more keywords
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Downregulation of thioredoxin-1-dependent CD95 S-nitrosation by Sorafenib reduces liver cancer

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recommendations! Published in 2020 at "Redox Biology"

DOI: 10.1016/j.redox.2020.101528

Abstract: Hepatocellular carcinoma (HCC) represents 80% of the primary hepatic neoplasms. It is the sixth most frequent neoplasm, the fourth cause of cancer-related death, and 7% of registered malignancies. Sorafenib is the first line molecular targeted… read more here.

Keywords: thioredoxin; downregulation; cancer; nitrosation ... See more keywords
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An efficient process for the synthesis of gem-dinitro compounds under high steric hindrance by nitrosation and oxidation of secondary nitroalkanes

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recommendations! Published in 2018 at "Tetrahedron Letters"

DOI: 10.1016/j.tetlet.2018.05.002

Abstract: Abstract A new nitrosation and oxidation process to synthesize gem -dinitro compounds was accomplished by using nitryl chloride as nitrosation reagent and ozone as oxidizing agent. The main features of the present protocol include the… read more here.

Keywords: gem; dinitro compounds; nitrosation oxidation; high steric ... See more keywords
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N-Nitrosation Mechanism Catalyzed by Non-heme Iron-Containing Enzyme SznF Involving Intramolecular Oxidative Rearrangement.

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recommendations! Published in 2021 at "Inorganic chemistry"

DOI: 10.1021/acs.inorgchem.1c00057

Abstract: The non-heme iron-dependent enzyme SznF catalyzes a critical N-nitrosation step during the N-nitrosourea pharmacophore biosynthesis in streptozotocin. The intramolecular oxidative rearrangement process is known to proceed at the FeII-containing active site in the cupin domain… read more here.

Keywords: mechanism; nitrosation; sznf; heme iron ... See more keywords
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S-Nitrosation of E3 Ubiquitin Ligase Complex Components Regulates Hormonal Signalings in Arabidopsis

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recommendations! Published in 2022 at "Frontiers in Plant Science"

DOI: 10.3389/fpls.2021.794582

Abstract: E3 ubiquitin ligases mediate the last step of the ubiquitination pathway in the ubiquitin-proteasome system (UPS). By targeting transcriptional regulators for their turnover, E3s play a crucial role in every aspect of plant biology. In… read more here.

Keywords: ligase complex; ubiquitin ligase; nitrosation ubiquitin; nitrosation ... See more keywords
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Proteomic Analysis of S-Nitrosation Sites During Somatic Embryogenesis in Brazilian Pine, Araucaria angustifolia (Bertol.) Kuntze

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recommendations! Published in 2022 at "Frontiers in Plant Science"

DOI: 10.3389/fpls.2022.902068

Abstract: Cysteine S-nitrosation is a redox-based post-translational modification that mediates nitric oxide (NO) regulation of various aspects of plant growth, development and stress responses. Despite its importance, studies exploring protein signaling pathways that are regulated by… read more here.

Keywords: embryogenesis; brazilian pine; somatic embryogenesis; embryogenesis brazilian ... See more keywords
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Deciphering the Path of S-nitrosation of Human Thioredoxin: Evidence of an Internal NO Transfer and Implication for the Cellular Responses to NO

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recommendations! Published in 2022 at "Antioxidants"

DOI: 10.3390/antiox11071236

Abstract: Nitric oxide (NO) is a free radical with a signaling capacity. Its cellular functions are achieved mainly through S-nitrosation where thioredoxin (hTrx) is pivotal in the S-transnitrosation to specific cellular targets. In this study, we… read more here.

Keywords: nitrosation human; deciphering path; nitrosation; thioredoxin ... See more keywords
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S-Nitrosoglutathione Reductase—The Master Regulator of Protein S-Nitrosation in Plant NO Signaling

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recommendations! Published in 2019 at "Plants"

DOI: 10.3390/plants8020048

Abstract: S-nitrosation has been recognized as an important mechanism of protein posttranslational regulations, based on the attachment of a nitroso group to cysteine thiols. Reversible S-nitrosation, similarly to other redox-base modifications of protein thiols, has a… read more here.

Keywords: protein; nitrosoglutathione reductase; plant; reductase master ... See more keywords