Microglial activation induces nitric oxide signalling and alters protein S‐nitrosylation patterns in extracellular vesicles
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12455
Abstract: Abstract Neuroinflammation is an underlying feature of neurodegenerative conditions, often appearing early in the aetiology of a disease. Microglial activation, a prominent initiator of neuroinflammation, can be induced through lipopolysaccharide (LPS) treatment resulting in expression… read more here.
Keywords: extracellular vesicles; neuroinflammation; microglial activation; nitric oxide ... See more keywords
Expression, S-Nitrosylation, and Measurement of S-Nitrosylation Ratio of Recombinant Galectin-2.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0430-4_6
Abstract: S-nitrosylation, which involves the coupling of an NO group to the reactive thiol of Cys residue(s) in a polypeptide, is an important posttranslational modification detected in a variety of proteins. Here, we present the S-nitrosylation… read more here.
Keywords: nitrosylation; recombinant galectin; measurement; ratio ... See more keywords
S-Nitrosylation Regulates Cell Survival and Death in the Central Nervous System
Sign Up to like & getrecommendations! Published in 2017 at "Neurochemical Research"
DOI: 10.1007/s11064-017-2303-z
Abstract: Nitric oxide (NO), which is produced from nitric oxide synthase, is an important cell signaling molecule that is crucial for many physiological functions such as neuronal death, neuronal survival, synaptic plasticity, and vascular homeostasis. This… read more here.
Keywords: death; cell survival; nervous system; central nervous ... See more keywords
Mechanisms and kinetics of heme iron nitrosylation in an in vitro gastro-intestinal model.
Sign Up to like & getrecommendations! Published in 2018 at "Food chemistry"
DOI: 10.1016/j.foodchem.2017.06.092
Abstract: Fresh red meat and cured meat consumption increases the risk of gastro-intestinal cancers and it is strongly suspected that nitrosylheme is implicated by stimulating the endogenous production of mutagenic aldehydes and N-nitroso compounds. To investigate… read more here.
Keywords: heme iron; nitrosylation; model; gastro intestinal ... See more keywords
Nitrosylation of imidazo[1,2-a]pyridines in metal free system
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Saudi Chemical Society"
DOI: 10.1016/j.jscs.2016.02.004
Abstract: Abstract An efficient nitrosylation of imidazo[1,2- a ]pyridines has been developed using tert-Butyl nitrite (TBN) as the NO resource. The nitrosylation protocol demonstrates broad compatibilities, with various functional groups such as halogen, Me, OMe, COOMe… read more here.
Keywords: nitrosylation; pyridines metal; metal free; imidazo pyridines ... See more keywords
Oral nitrite treatment increases S-nitrosylation of vascular protein kinase C and attenuates the responses to angiotensin II
Sign Up to like & getrecommendations! Published in 2020 at "Redox Biology"
DOI: 10.1016/j.redox.2020.101769
Abstract: Nitrate and nitrite supplement deficient endogenous nitric oxide (NO) formation. While these anions may generate NO, recent studies have shown that circulating nitrite levels do not necessarily correlate with the antihypertensive effect of oral nitrite… read more here.
Keywords: responses angiotensin; pkc nitrosylation; oral nitrite; nitrosylation ... See more keywords
Protein S-Nitrosylation Regulates Postmortem Beef Apoptosis through the Intrinsic Mitochondrial Pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c06516
Abstract: The objective of the present study was to investigate the regulatory mechanism of protein S-nitrosylation on early postmortem beef muscle apoptosis. Beef semimembranosus (SM) muscles at 45 min postmortem were treated with nitric oxide (NO)… read more here.
Keywords: apoptosis; nitrosylation; protein nitrosylation; pathway ... See more keywords
Discovery of a Compound That Inhibits IRE1α S-Nitrosylation and Preserves the Endoplasmic Reticulum Stress Response under Nitrosative Stress
Sign Up to like & getrecommendations! Published in 2024 at "ACS Chemical Biology"
DOI: 10.1021/acschembio.4c00403
Abstract: Inositol-requiring enzyme 1α (IRE1α) is a sensor of endoplasmic reticulum (ER) stress and drives ER stress response pathways. Activated IRE1α exhibits RNase activity and cleaves mRNA encoding X-box binding protein 1, a transcription factor that… read more here.
Keywords: reticulum stress; stress; response; endoplasmic reticulum ... See more keywords
S-Nitrosylation of OTUB1 Alters Its Stability and Ubc13 Binding.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.1c00855
Abstract: S-Nitrosylation is a reversible post-translational modification that regulates protein function involving the covalent attachment of the nitric oxide (NO) moiety to sulfhydryl residues of the protein. It is an important regulator in the cell signaling… read more here.
Keywords: nitrosylation; otub1; otub1 alters; stability ubc13 ... See more keywords
S-nitrosylation of NOS pathway mediators in the penis contributes to cavernous nerve injury-induced erectile dysfunction
Sign Up to like & getrecommendations! Published in 2018 at "International journal of impotence research"
DOI: 10.1038/s41443-018-0021-y
Abstract: AbstractcGMP-independent nitric oxide (NO) signaling occurs via S-nitrosylation. We evaluated whether aberrant S-nitrosylation operates in the penis under conditions of cavernous nerve injury and targets proteins involved in regulating erectile function. Adult male Sprague–Dawley rats… read more here.
Keywords: bcni; nitrosylation; nac treatment; function ... See more keywords
Metabolic reprogramming by the S-nitroso-CoA Reductase system protects from kidney injury
Sign Up to like & getrecommendations! Published in 2018 at "Nature"
DOI: 10.1038/s41586-018-0749-z
Abstract: Endothelial nitric oxide synthase (eNOS) is protective against kidney injury, but the molecular mechanisms of this protection are poorly understood1,2. Nitric oxide-based cellular signalling is generally mediated by protein S-nitrosylation, the oxidative modification of Cys… read more here.
Keywords: kidney injury; system; sno coa; nitrosylation ... See more keywords