A modular scaffold for triggerable and tunable nitroxyl (HNO) generation with a fluorescence reporter.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d2cc06134a
Abstract: Nitroxyl (HNO) is a short-lived mediator of cell signalling and can enhance the sulfane sulfur pool, a cellular antioxidant reservoir, by reacting with hydrogen sulfide (H2S). Here, we report esterase-activated HNO-generators that are suitable for… read more here.
Keywords: tunable nitroxyl; nitroxyl hno; triggerable tunable; modular scaffold ... See more keywords
Vasoprotective Actions of Nitroxyl (HNO): a Story of Sibling Rivalry.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cardiovascular pharmacology"
DOI: 10.1097/fjc.0000000000001151
Abstract: ABSTRACT Nitroxyl (HNO), the one electron reduced and protonated form of nitric oxide (NO•), has emerged as a nitrogen oxide with a suite of vasoprotective properties and therapeutic advantages over its redox sibling. Whilst HNO… read more here.
Keywords: hno story; nitroxyl hno; vasoprotective actions; sibling rivalry ... See more keywords
Mechanisms Associated to Nitroxyl (HNO)-Induced Relaxation in the Intestinal Smooth Muscle
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2020.00438
Abstract: The pharmacological properties of nitroxyl (HNO) donors in the gastrointestinal tract are unknown. We investigated the properties of this molecule in the regulation of gastrointestinal contractility focusing on its possible interaction with other gaseous signaling… read more here.
Keywords: inhibitor; relaxation; hno; muscle ... See more keywords