All-Atom Simulations Reveal the Effect of Membrane Composition on the Signaling of the NKG2A/CD94/HLA-E Immune Receptor Complex
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Chemical Information and Modeling"
DOI: 10.1021/acs.jcim.4c01357
Abstract: Understanding how membrane composition influences the dynamics and function of transmembrane proteins is crucial for the comprehensive elucidation of cellular signaling mechanisms and the development of targeted therapeutics. In this study, we employed all-atom molecular… read more here.
Keywords: nkg2a cd94; membrane composition; cd94 hla; membrane ... See more keywords
Thermal‐exchange HLA‐E multimers reveal specificity in HLA‐E and NKG2A/CD94 complex interactions
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DOI: 10.1111/imm.13591
Abstract: There is growing interest in HLA‐E‐restricted T‐cell responses as a possible novel, highly conserved, vaccination targets in the context of infectious and malignant diseases. The developing field of HLA multimers for the detection and study… read more here.
Keywords: nkg2a cd94; thermal exchange; hla multimers; hla ... See more keywords
Abstract 116: Generation of humanized PD-1/PD-L1/CD94/NKG2A mice for evaluating novel combination therapies
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DOI: 10.1158/1538-7445.am2024-116
Abstract: NKG2A and its co-receptor, CD94, are expressed on the surface of NK cells, and function to send inhibitory signals to NK cells upon recognition of the HLA-E complex on adjacent cells. Blockade of the NKG2A/CD94… read more here.
Keywords: mice; humanized cd94; combination; nkg2a cd94 ... See more keywords
What a Difference an Amino Acid Makes: An All-Atom Simulation Study of Nonameric Peptides in Inhibitory HLA-E/NKG2A/CD94 Immune Complexes
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.925427
Abstract: MHC class I antigen E (HLA-E), a ligand for the inhibitory NKG2A/CD94 receptor of the immune system, is responsible for evading the immune surveillance in several settings, including senescent cell accumulation and tumor persistence. The… read more here.
Keywords: hla nkg2a; nkg2a cd94; immune; study ... See more keywords