A signature based on NKG2D ligands to predict the recurrence of hepatocellular carcinoma after radical resection
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5318
Abstract: Due to the high recurrence, the HCC prognosis remains poor. Yet, the biomarkers for predicting the recurrence of high‐risk patients are currently lacking. We aimed to develop a signature to predict the recurrence of HCC… read more here.
Keywords: predict recurrence; nkg2d ligands; based nkg2d; recurrence ... See more keywords
Expressions of natural cytotoxicity receptor, NKG2D and NKG2D ligands in endometriosis.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of reproductive immunology"
DOI: 10.1016/j.jri.2019.102615
Abstract: Pathogenesis of endometriosis is still unknown, and the relationship between NK cell activating receptors and endometriosis remains to be explored. We investigated the expression of NCRs and NKG2D in NK cells in peripheral blood (PB)… read more here.
Keywords: endometriosis; nkg2d ligands; nkg2d cells; endometriosis expressions ... See more keywords
NKG2D and its ligands as cytotoxic factors in cutaneous lupus erythematosus
Sign Up to like & getrecommendations! Published in 2021 at "Experimental Dermatology"
DOI: 10.1111/exd.14311
Abstract: Cutaneous lupus erythematosus (CLE) is an autoimmune skin disorder that is characterized by an anti‐epidermal lymphocytic infiltrate invading the dermo‐epidermal junction, causing an interface dermatitis (ID). Pathogenesis of CLE has been linked to activation of… read more here.
Keywords: nkg2d ligands; erythematosus; lupus erythematosus; skin ... See more keywords
Rapamycin downregulates NKG2D ligands in acute myeloid leukemia cells via an activation of the STAT3 pathway: a potential mechanism for rapamycin-induced immune escape in leukemia
Sign Up to like & getrecommendations! Published in 2019 at "Translational cancer research"
DOI: 10.21037/27578
Abstract: Background: The constitutive activation of the mammalian target of rapamycin (mTOR) is involved in the pathogenesis of many cancers. Rapamycin (RAPA), a specific inhibitor of mTOR, has been applied to the clinical treatment of tumors,… read more here.
Keywords: nkg2d ligands; aml cells; acute myeloid; leukemia ... See more keywords
Rapamycin downregulates NKG2D ligands in acute myeloid leukemia cells via an activation of the STAT3 pathway: a potential mechanism for rapamycin-induced immune escape in leukemia
Sign Up to like & getrecommendations! Published in 2019 at "Translational Cancer Research"
DOI: 10.21037/tcr.2019.03.01
Abstract: Background The constitutive activation of the mammalian target of rapamycin (mTOR) is involved in the pathogenesis of many cancers. Rapamycin (RAPA), a specific inhibitor of mTOR, has been applied to the clinical treatment of tumors,… read more here.
Keywords: acute myeloid; nkg2d ligands; aml cells; rapamycin ... See more keywords
MAPK inhibitors dynamically affect melanoma release of immune NKG2D-ligands, as soluble protein and extracellular vesicle-associated
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.1055288
Abstract: Metastatic melanoma presents, in many cases, oncogenic mutations in BRAF, a MAPK involved in proliferation of tumour cells. BRAF inhibitors, used as therapy in patients with these mutations, often lead to tumour resistance and, thus,… read more here.
Keywords: melanoma; mapk inhibitors; soluble protein; vesicle ... See more keywords
Mechanisms of Senescence-Related NKG2D Ligands Release and Immune Escape Induced by Chemotherapy in Neuroblastoma Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.829404
Abstract: Chemotherapy-induced senescence promotes immunocyte aggregation in the tumor microenvironment by upregulating the surface expression of activating ligands in cancer cells. However, these senescent tumor cells cannot be completely cleared and can induce tumor recurrence. Previous… read more here.
Keywords: tumor; mir 92a; nkg2d ligands; senescence ... See more keywords
Disarming Cellular Alarm Systems—Manipulation of Stress-Induced NKG2D Ligands by Human Herpesviruses
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2017.00390
Abstract: The coevolution of viruses and their hosts led to the repeated emergence of cellular alert signals and viral strategies to counteract them. The herpesvirus family of viruses displays the most sophisticated repertoire of immune escape… read more here.
Keywords: disarming cellular; nkg2d ligands; alarm systems; systems manipulation ... See more keywords
More than Decoration: Roles for Natural Killer Group 2 Member D Ligand Expression by Immune Cells
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.00231
Abstract: The activating immune receptor natural killer group 2 member D (NKG2D), which is expressed by natural killer cells and T cell subsets, recognizes a number of ligands expressed by “stressed” or damaged cells. NKG2D has… read more here.
Keywords: nkg2d ligands; natural killer; expression; killer group ... See more keywords
New Insights Into the Regulation of Natural-Killer Group 2 Member D (NKG2D) and NKG2D-Ligands: Endoplasmic Reticulum Stress and CEA-Related Cell Adhesion Molecule 1
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.01324
Abstract: Natural-killer group 2 member D (NKG2D) is a well-characterized activating receptor expressed by natural killer (NK) cells, NKT cells, activated CD8+ T cells, subsets of γδ+ T cells, and innate-like T cells. NKG2D recognizes multiple… read more here.
Keywords: nkg2d ligands; natural killer; stress; killer group ... See more keywords
The HHV-6A Proteins U20 and U21 Target NKG2D Ligands to Escape Immune Recognition
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.714799
Abstract: The coevolution of the human immune system and herpesviruses led to the emergence and diversification of both cellular danger molecules recognized by immune cells on the one hand and viral countermeasures that prevent the expression… read more here.
Keywords: nkg2d ligands; immune recognition; recognition; escape immune ... See more keywords