New Paradigm in NKT Cell Antigens: MCS‐0208 (2‐(Hydroxymethyl)phenylthio‐phytoceramide) – an Aryl‐Phytoceramide Compound with a Single Hydroxyl Group Stimulates NKT Cells
Sign Up to like & getrecommendations! Published in 2021 at "Chemmedchem"
DOI: 10.1002/cmdc.202000992
Abstract: Natural Killer T (NKT) cells play an important role in the immune response and can be activated by glycolipids presented by CD1d protein. We present MCS‐0208, an unprecedented arylthioether‐phytoceramide able to induce potent invariant NKT… read more here.
Keywords: single hydroxyl; mcs 0208; nkt cells; nkt cell ... See more keywords
Complexity and function of natural killer T cells with potential application to hepatic transplant survival
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DOI: 10.1002/lt.24950
Abstract: One of the major innate‐like lymphocyte populations enriched in the liver consists of natural killer T (NKT) cells, which recognize self and foreign lipid antigens presented by the nonpolymorphic class I major histocompatibility complex–like molecule… read more here.
Keywords: killer; complexity function; natural killer; nkt cells ... See more keywords
NKT cells are responsible for the clearance of murine norovirus through the virus-specific secretory IgA pathway
Sign Up to like & getrecommendations! Published in 2020 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2019.100722
Abstract: Norovirus infection cause epidemic nonbacterial gastroenteritis in patients. The immune mechanisms responsible for the clearance of virus are not completely understood. We examined whether NKT cells are effective against norovirus infection using CD1d KO mice.… read more here.
Keywords: cd1d mice; infection; nkt cells; clearance ... See more keywords
NKT cells in cardiovascular diseases.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2017.03.052
Abstract: Despite life-style advice and the prescription of cholesterol-lowering and anti-thrombotic drugs, cardiovascular diseases are still the leading cause of death worldwide. Therefore, there is an urgent need for new therapeutic strategies focussing on atherosclerosis, the… read more here.
Keywords: cells cardiovascular; nkt cells; cardiovascular diseases; pathology ... See more keywords
CD8dim but not CD8bright cells positive to CD56 dominantly express KIR and are cytotoxic during visceral leishmaniasis.
Sign Up to like & getrecommendations! Published in 2018 at "Human immunology"
DOI: 10.1016/j.humimm.2018.05.004
Abstract: This study reports a structural and functional heterogeneity of CD8+CD56+NKT cells, which usually decrease quantitatively during visceral leishmaniasis. Based on fluorescence intensity of CD8 receptors on CD56+NKT cells, two populations of CD8+CD56+NKT cells have been… read more here.
Keywords: cd56 nkt; cd8brightcd56 nkt; nkt cells; visceral leishmaniasis ... See more keywords
GM-CSF and IL-4 produced by NKT cells inversely regulate IL-1β production by macrophages.
Sign Up to like & getrecommendations! Published in 2017 at "Immunology letters"
DOI: 10.1016/j.imlet.2017.01.003
Abstract: Natural Killer T (NKT) cells are distinct T cell subset that link innate and adaptive immune responses. IL-1β, produced by various immune cells, plays a key role in the regulation of innate immunity in vivo.… read more here.
Keywords: production; nkt cells; production macrophages; regulate production ... See more keywords
Expression of NK cell receptor ligands in primary colorectal cancer tissue in relation to the phenotype of circulating NK- and NKT cells, and clinical outcome.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular immunology"
DOI: 10.1016/j.molimm.2020.10.012
Abstract: INTRODUCTION Natural killer (NK) cells and natural killer T (NKT) cells are implicated in the development and progression of colorectal cancer (CRC). Tumor cells express NK cell receptor ligands that modulate their function. This study… read more here.
Keywords: circulating nkt; nkt cells; expression; receptor ... See more keywords
TCRα-TCRβ pairing controls recognition of CD1d and directs the development of adipose NKT cells
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DOI: 10.1038/ni.3622
Abstract: The interaction between the T cell antigen receptor (TCR) expressed by natural killer T cells (NKT cells) and the antigen-presenting molecule CD1d is distinct from interactions between the TCR and major histocompatibility complex (MHC). Our… read more here.
Keywords: development; recognition cd1d; nkt cells; tcr ... See more keywords
Natural killer T cells in atherosclerosis
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DOI: 10.1038/nrcardio.2017.2
Abstract: Atherosclerosis is a chronic inflammatory disorder that develops in response to hyperlipidaemia. Cells from both the innate and adaptive immune systems contribute to the development of atherosclerotic lesions. The role of natural killer T (NKT)… read more here.
Keywords: cells atherosclerosis; natural killer; nkt cells; killer cells ... See more keywords
Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors
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DOI: 10.1038/s41467-019-12941-9
Abstract: Type I and type II natural killer T (NKT) cells are restricted to the lipid antigen-presenting molecule CD1d. While we have an understanding of the antigen reactivity and function of type I NKT cells, our… read more here.
Keywords: nkt cells; antigen; type; cell ... See more keywords
Suppression of R5-type of HIV-1 in CD4+ NKT cells by Vδ1+ T cells activated by flavonoid glycosides, hesperidin and linarin
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DOI: 10.1038/s41598-019-40587-6
Abstract: We established transfectants expressing T cell receptors (TCRs) either for Vγ1 and Vδ1 (1C116) or for Vγ2 and Vδ2 (2C21) using the TCR-deficient Jurkat T cell line J.RT3-T3.5. The amount of IL-2 secreted from these… read more here.
Keywords: hesperidin linarin; cd4 nkt; nkt cells; flavonoid glycosides ... See more keywords