Abstract 1603: NKTR-255 engages the IL-15 pathway driving CD8 T cell survival and CD8 memory T cell proliferation
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-1603
Abstract: Background: IL-15, an immunostimulatory cytokine, plays an important role in both the innate and adaptive immune system. Notably, this pleiotropic cytokine is a key regulator of homeostasis and survival of CD8 and CD8 memory T… read more here.
Keywords: nktr 255; cd8; proliferation; cd8 memory ... See more keywords
Abstract 3265: NKTR-255, a polymer-conjugated IL-15 enhances anti-tumor NK cell responses and synergizes with monoclonal antibodies to provide long-term survival in human lymphoma model
Sign Up to like & getrecommendations! Published in 2019 at "Immunology"
DOI: 10.1158/1538-7445.am2019-3265
Abstract: Background: IL-15 is a cytokine that activates and provides survival benefit to NK cells. Exploiting the therapeutic value of native IL-15 has been challenging due to its unfavorable pharmacokinetic properties and tolerability. NKTR-255 is a… read more here.
Keywords: nktr 255; monoclonal antibodies; lymphoma model; tumor ... See more keywords
Abstract 1152: NKTR-255, a polymer-conjugated IL-15, dramatically improves ROR1 CAR-T cell persistence and anti-tumor efficacy in an autochthonous model of ROR1+ lung cancer
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DOI: 10.1158/1538-7445.am2023-1152
Abstract: CAR-T cells have mediated remarkable clinical responses against hematological malignancies, but this success has yet to extend to solid tumors, where many factors in the tumor microenvironment (TME) inhibit their persistence and function. In a… read more here.
Keywords: nktr 255; tumor; car; ror1 ... See more keywords
NKTR-255, a Polymer-Conjugated IL-15 Enhances Antibody-Dependent Cellular Cytotoxicity Mediated By NK Cells in a B Cell Lymphoma Model
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DOI: 10.1182/blood-2019-127771
Abstract: Background IL-15 is a cytokine that activates and provides survival benefit to T and NK cells and has great potential as an immunotherapeutic agent for the treatment of cancer. Exploiting the therapeutic value of native… read more here.
Keywords: nktr 255; equity ownership; nektar therapeutics; treatment ... See more keywords
Restoring Innate and Adaptive Immune Repertoire in Multiple Myeloma for Therapeutic Application
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DOI: 10.1182/blood-2019-128767
Abstract: Despite advances and improvements in survival, majority of multiple myeloma (MM) patients ultimately relapses. Extensive analysis on the properties of tumor cells has provided interesting insights into the disease biology allowing for the identification of… read more here.
Keywords: immune; nktr 255; effector; innate adaptive ... See more keywords