The multiple roles of the NlpC_P60 peptidase family in mycobacteria – an underexplored target for antimicrobial drug discovery
Sign Up to like & getrecommendations! Published in 2025 at "Febs Letters"
DOI: 10.1002/1873-3468.70021
Abstract: The main function of the cell wall is to maintain cellular integrity throughout the cell cycle by keeping the cell shape during growth and division. However, far from being a static structure, the cell wall… read more here.
Keywords: multiple roles; nlpc p60; physiology; cell wall ... See more keywords
Deletion of a putative NlpC/P60 endopeptidase BAS1812 affects germination, long-term survival and endospore formation in Bacillus anthracis.
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DOI: 10.1099/mic.0.000416
Abstract: Bacillus anthracis, an aetiologic agent of the zoonotic disease anthrax, encodes a putative NlpC/P60 endopeptidase BAS1812. It harbours a signal peptide, three bacterial SH3 domains and an NlpC/P60 family domain. Previous studies showed that BAS1812… read more here.
Keywords: germination; bacillus anthracis; putative nlpc; bas1812 ... See more keywords
An NlpC/P60 protein catalyzes a key step in peptidoglycan recycling at the intersection of energy recovery, cell division and immune evasion in the intracellular pathogen Chlamydia trachomatis
Sign Up to like & getrecommendations! Published in 2022 at "PLOS Pathogens"
DOI: 10.1371/journal.ppat.1011047
Abstract: The obligate intracellular Chlamydiaceae do not need to resist osmotic challenges and thus lost their cell wall in the course of evolution. Nevertheless, these pathogens maintain a rudimentary peptidoglycan machinery for cell division. They build… read more here.
Keywords: cell; nlpc p60; cell division; energy ... See more keywords