Chronic dexamethasone treatment results in hippocampal neurons injury due to activate NLRP1 inflammasome in vitro
Sign Up to like & getrecommendations! Published in 2017 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2017.05.039
Abstract: &NA; Neuroinflammation mediated by NLRP‐1 inflammasome plays an important role in the pathogenesis of neurodegeneration diseases such as Alzheimer's disease (AD). Chronic glucocorticoids (GCs) exposure has deleterious effect on the structure and function of neurons… read more here.
Keywords: gcs exposure; hippocampal neurons; exposure; nlrp1 inflammasome ... See more keywords
NADPH oxidase 2‐mediated NLRP1 inflammasome activation involves in neuronal senescence in hippocampal neurons in vitro
Sign Up to like & getrecommendations! Published in 2019 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2019.01.025
Abstract: &NA; Oxidative stress and inflammation are closely related to neuron ageing. NADPH oxidase 2 (NOX2) is a major source of reactive oxygen species (ROS) generation in brain. The nucleotide‐binding oligomerisation domain (NOD)‐like receptor protein 1… read more here.
Keywords: nadph oxidase; nlrp1 inflammasome; hippocampal neurons; neuronal damage ... See more keywords
1,25-Dihydroxyvitamin D3 attenuates IL-1β secretion by suppressing NLRP1 inflammasome activation by upregulating the NRF2-HO-1 pathway in epidermal keratinocytes.
Sign Up to like & getrecommendations! Published in 2021 at "Redox biology"
DOI: 10.1016/j.redox.2021.102203
Abstract: The nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing protein (NLRP) inflammasome is a key inflammatory signaling pathway activated via a two-step signaling process consisting of priming and activation steps. Several studies have shown that 1,25-dihydroxyvitamin… read more here.
Keywords: inflammasome activation; activation; nigericin induced; secretion ... See more keywords
Immersion in Water Between 20-30oC Mediated Inflammations Marker to Reduced Pain Among Indonesian With Gout Arthritis: A Community-Based Randomized Controlled Trial
Sign Up to like & getrecommendations! Published in 2022 at "Biological Research For Nursing"
DOI: 10.1177/10998004221132843
Abstract: Background Gout is triggered by high urate levels and causes inflammation, pain, and an impaired quality of life. Immersion in water at 20–30°C reduces inflammation and pain in arthritis. Yet, relationships of immersion in water… read more here.
Keywords: water; urate levels; nlrp1 inflammasome; pain ... See more keywords
Schisandrin Inhibits NLRP1 Inflammasome-Mediated Neuronal Pyroptosis in Mouse Models of Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2021 at "Neuropsychiatric Disease and Treatment"
DOI: 10.2147/ndt.s279147
Abstract: Background In recent years, schisandrin (SCH) was proved to improve Alzheimer's Disease (AD). The aim of our study is to explore the effect of SCH on neuronal pyroptosis in the disease. Methods A Morris water… read more here.
Keywords: nlrp1 inflammasome; neuronal apoptosis; neuronal pyroptosis; pyroptosis ... See more keywords
The CARD8 T60 variant associates with NLRP1 and negatively regulates its activation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1047922
Abstract: The NLRP1 inflammasome functions as canonical cytosolic sensor in response to intracellular infections and is implicated in auto-inflammatory diseases. But the regulation and signal transduction mechanisms of NLRP1 are incompletely understood. Here, we show that… read more here.
Keywords: card8; t60 variant; nlrp1 inflammasome; negatively regulates ... See more keywords
The Role and Mechanism of Hyperoside against Depression-like Behavior in Mice via the NLRP1 Inflammasome
Sign Up to like & getrecommendations! Published in 2022 at "Medicina"
DOI: 10.3390/medicina58121749
Abstract: Background and Objectives: Hypericum perforatum (HP) is widely used for depressive therapy. Nevertheless, the antidepressant effect and potential mechanism of hyperoside (Hyp), the main active component of HP, have not been determined. Materials and Methods:… read more here.
Keywords: mechanism hyperoside; pharmacology; active components; depression ... See more keywords
Ginsenoside Rg1 protects against H2O2-induced neuronal damage due to inhibition of the NLRP1 inflammasome signalling pathway in hippocampal neurons in vitro
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Medicine"
DOI: 10.3892/ijmm.2018.4005
Abstract: Oxidative stress and neuroinflammation are important in the pathogenesis of ageing and age-related neurodegenerative diseases, including Alzheimer’s disease. NADPH oxidase 2 (NOX2) is a major source of reactive oxygen species (ROS) in the brain. The… read more here.
Keywords: hippocampal neurons; inflammasome signalling; rg1; nlrp1 inflammasome ... See more keywords