122. Silibinin regulates the NF-κB pathway and NLRP1/NLRP3 inflammasomes induced by monosodium urate in monocytes from preeclamptic women and THP-1 cells
Sign Up to like & getrecommendations! Published in 2018 at "Pregnancy Hypertension"
DOI: 10.1016/j.preghy.2018.08.237
Abstract: Introduction Preeclampsia (PE) is characterized by a state of abnormal activation of the innate immune system. It’s associated with hyperuricemia and elevated serum levels of inflammatory cytokines. Uric acid crystals can activate inflammasome, a multiprotein… read more here.
Keywords: preeclamptic women; inflammatory cytokines; nlrp1 nlrp3; silibinin ... See more keywords
IL-1α and TNF-α as an inducer for ROS-mediated NLRP1/NLRP3 inflammasomes activation in mononuclear blood cells from individuals with chronic insomnia disorder.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of neurology"
DOI: 10.1111/ene.15540
Abstract: BACKGROUND There are some evidence that cytokines may play an important role in sleep deprivation; however, the underlying mechanisms are still unknown. So, the present study aim to evaluate the relationship between NLRP1 and NLRP3… read more here.
Keywords: nlrp1 nlrp3; blood cells; nlrp3 inflammasomes; individuals cid ... See more keywords
Frequency of Interleukins IL1ß/IL18 and Inflammasome NLRP1/NLRP3 Polymorphisms in Sickle Cell Anemia Patients and their Association with Severity Score
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DOI: 10.2174/1566524019666190826143749
Abstract: Interleukins IL1ß/IL18 and Inflammasome NLRP1/NLRP3 polymorphisms can change the course of multiple human diseases, both inflammatory as infectious. SNPs these proteins were associated with the constructive activation of the Inflammasome and excessive production of IL-1β… read more here.
Keywords: inflammasome nlrp1; il18 inflammasome; il1 il18; nlrp1 nlrp3 ... See more keywords
The Role of NLRP1, NLRP3, and AIM2 Inflammasomes in Psoriasis: Review
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DOI: 10.3390/ijms22115898
Abstract: Inflammasomes are high-molecular-weight protein complexes that may cleave the two main proinflammatory cytokines, pro-interleukin-1β and pro-interleukin-18, into active forms, and contribute to psoriasis. Despite recent advances made in the pathogenesis of psoriasis, mainly studied as… read more here.
Keywords: nlrp1 nlrp3; nlrp3 aim2; psoriasis; pathogenesis psoriasis ... See more keywords