NLRP3 overexpression exacerbated synovium tissue degeneration in juvenile collagen-induced arthritis
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DOI: 10.1038/s41598-025-86720-6
Abstract: Juvenile idiopathic arthritis (JIA) can lead to synovial inflammation. JIA is a chronic autoimmune inflammatory condition that primarily affects children. It is recognized as the most prevalent form of arthritis in the pediatric population and… read more here.
Keywords: jia; juvenile; cia; nlrp3 ... See more keywords
Discovery of natural product derivative triptolidiol as a direct NLRP3 inhibitor by reducing K63‐specific ubiquitination
Sign Up to like & getrecommendations! Published in 2024 at "British Journal of Pharmacology"
DOI: 10.1111/bph.17320
Abstract: NLRP3 is up‐regulated in inflammatory and autoimmune diseases. The development of NLRP3 inhibitors is challenged by the identification of compounds with distinct mechanisms of action avoiding side effects and toxicity. Triptolide is a natural product… read more here.
Keywords: derivative triptolidiol; natural product; discovery natural; nlrp3 ... See more keywords
NLRP3 Plays a Key Role in Antihelminth Immunity in the Enteral and Parenteral Stages of Trichinella spiralis-Infected Mice
Sign Up to like & getrecommendations! Published in 2023 at "Infection and Immunity"
DOI: 10.1128/iai.00382-22
Abstract: Trichinellosis is an important foodborne zoonosis, and no effective treatments are yet available. Nod-like receptor (NLR) plays a critical role in the host response against nematodes. ABSTRACT Trichinellosis is an important foodborne zoonosis, and no… read more here.
Keywords: role; infection; stages trichinella; mice ... See more keywords
Loss of NLRP3 increases bacterial cystitis via IRAKM
Sign Up to like & getrecommendations! Published in 2022 at "Translational Andrology and Urology"
DOI: 10.21037/tau-22-67
Abstract: Background We attempted to characterize the molecular mechanisms that underpin urinary tract infections using a mouse model of cystitis induced by bacterial infection in a background of NOD-, LRR- and PYD domains-containing protein (NLRP3) deficiency.… read more here.
Keywords: day; cystitis; infection; control mice ... See more keywords
Novel chemotype NLRP3 inhibitors that target the CRID3-binding pocket with high potency
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DOI: 10.26508/lsa.202402644
Abstract: The NLRP3 inflammasome drives various diseases. Here, we describe novel potent and selective NLRP3-targeted inhibitors to bolster pharmacological studies and development of NLRP3-targeted therapies. The NLRP3 inflammasome plays a central role in various human diseases.… read more here.
Keywords: potent selective; nlrp3 targeted; potency; nlrp3 inflammasome ... See more keywords
Behçet's Syndrome in a Chinese Pedigree of NLRP3-Associated Autoinflammatory Disease: A Coexistence or Novel Presentation?
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2021.695197
Abstract: Objectives: NLRP3-associated autoinflammatory disease (NLRP3-AID) and Behçet's syndrome (BS) both belong to autoinflammatory diseases and rarely co-occur. Here we reported a Chinese pedigree of NLRP3-AID presented with BS. Methods: We recorded a Chinese pedigree of… read more here.
Keywords: nlrp3 aid; chinese pedigree; nlrp3 associated; pedigree nlrp3 ... See more keywords
A novel optical imaging probe for targeted visualization of NLRP3 inflammasomes in a mouse model of age-related macular degeneration
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.1047791
Abstract: Purpose Wet form of age-related macular degeneration (wet AMD) is a progressive vascular disease that mainly affects older adults and causes severe and irreversible vision loss. A key complication of wet AMD is choroidal neovascularization… read more here.
Keywords: age related; imaging probe; nlrp3 inflammasomes; inflammaprobe ... See more keywords