Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-24784-4
Abstract: The NLRP3 inflammasome mediates the production of proinflammatory cytokines and initiates inflammatory cell death. Although NLRP3 is essential for innate immunity, aberrant NLRP3 inflammasome activation contributes to a wide variety of inflammatory diseases. Understanding the… read more here.
Keywords: inflammasome activation; activation pyroptosis; activation; nlrp3 inflammasome ... See more keywords
NLRP3 activation in neutrophils induces lethal autoinflammation, liver inflammation, and fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "EMBO reports"
DOI: 10.15252/embr.202154446
Abstract: Sterile inflammation is a central element in liver diseases. The immune response following injurious stimuli involves hepatic infiltration of neutrophils and monocytes. Neutrophils are major effectors of liver inflammation, rapidly recruited to sites of inflammation,… read more here.
Keywords: nlrp3 activation; inflammation; liver inflammation; inflammation fibrosis ... See more keywords