Isoformononetin, a dietary isoflavone protects against streptozotocin induced rat model of neuroinflammation through inhibition of NLRP3/ASC/IL-1 axis activation.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119989
Abstract: AIMS Isoformononetin (IFN), a methoxyl isoflavone present in most of human dietary supplements. However, being a highly potent antioxidant and anti-inflammatory molecule, its activity against neuronal oxidative stress and neuroinflammation has not been explored till… read more here.
Keywords: nlrp3 asc; streptozotocin induced; asc; neuroinflammation ... See more keywords
Prenatal Sevoflurane Exposure Impairs the Learning and Memory of Rat Offspring via HMGB1-Induced NLRP3/ASC Inflammasome Activation.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00620
Abstract: The neurotoxic effects of sevoflurane anesthesia on the immature nervous system have aroused public concern, but the specific effects and mechanism remain poorly understood. Pyroptosis caused by the activation of the NLRP3 inflammasome is pivotal… read more here.
Keywords: sevoflurane exposure; sevoflurane; asc inflammasome; sevoflurane induced ... See more keywords
miR-155-5p/FOXO3a promotes pulmonary fibrosis in rats by mediating NLRP3 inflammasome activation
Sign Up to like & getrecommendations! Published in 2022 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2022.2115923
Abstract: Abstract Objective Pulmonary fibrosis (PF) is regarded as progressive lung disease. miR-155-5p depletion exerts anti-fibrotic effects in silicotic mice. This study explored the effect and possible mechanism of miR-155-5p in PF rats, hoping to find… read more here.
Keywords: mir 155; pulmonary fibrosis; foxo3a; nlrp3 asc ... See more keywords
Qiqilian ameliorates vascular endothelial dysfunction by inhibiting NLRP3-ASC inflammasome activation in vivo and in vitro.
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutical biology"
DOI: 10.1080/13880209.2023.2208617
Abstract: CONTEXT Previous studies have highlighted significant therapeutic effects of Qiqilian (QQL) capsule on hypertension in spontaneously hypertensive rats (SHRs); however, its underlying molecular mechanism remains unclear. OBEJECTIVE We investigated the potential mechanism by which QQL… read more here.
Keywords: group; angii induced; nlrp3 asc; endothelial dysfunction ... See more keywords
Effect of NLRP3 repression on NLRP3 inflammasome activation in human corneal epithelial cells with black carbon exposure
Sign Up to like & getrecommendations! Published in 2022 at "Cutaneous and Ocular Toxicology"
DOI: 10.1080/15569527.2022.2050746
Abstract: Abstract Purpose To investigate the inhibitory effects of NLRP3 siRNA on NLRP3 inflammasome activation in human corneal epithelial cells (HCECs) with fresh black carbon (FBC) particles and ozone-oxidized BC (OBC) particles treatment. Methods HCECs were… read more here.
Keywords: mrna levels; protein levels; nlrp3 asc; nlrp3 sirna ... See more keywords
Alleviation of chemotherapy-induced acute lung injury via NLRP3/ ASC/ Caspase-1 signaling pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Toxicology research"
DOI: 10.1093/toxres/tfac021
Abstract: Acute lung injury has been reported following various chemotherapeutic agents administration. Several pathways for lung injury have been speculated however, the exact mechanism of the lung injury induced by methotrexate (MTX) is yet to be… read more here.
Keywords: lung injury; mtx; induced lung; nlrp3 asc ... See more keywords
Activation of NLRP3 inflammasome in macrophages by mycoplasmal lipoproteins and lipopeptides
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Oral Microbiology"
DOI: 10.1111/omi.12225
Abstract: The NLRP3 inflammasome, an intracellular sensor consisting of the nucleotide-binding oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3), the adaptor protein apoptosis-associated speck-like protein containing a caspase-recruitment domain (ASC), and procaspase-1, plays critical roles… read more here.
Keywords: nlrp3 asc; inflammasome macrophages; production; activation nlrp3 ... See more keywords
TIGAR deficiency induces caspase-1-dependent trophoblasts pyroptosis through NLRP3-ASC inflammasome
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1114620
Abstract: Introduction Gestational diabetes mellitus (GDM), a common complication of pregnancy, is risky for both mother and fetus. Previous studies about TP53-induced glycolysis and apoptosis regulator (TIGAR) focused on the occurrence and development of cancer, cardiovascular… read more here.
Keywords: tigar; pyroptosis; asc inflammasome; nlrp3 asc ... See more keywords