Efficacy of canakinumab on AA amyloidosis in late-onset NLRP3-associated autoinflammatory disease with an I574F somatic mosaic mutation
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DOI: 10.1007/s10067-022-06130-1
Abstract: There have been hundreds of reports on mutations in the NLRP3 gene related to NLRP3-associated autoinflammatory disease, but few of these mutations have occurred as both germline and somatic mosaic mutations. In this case-based review,… read more here.
Keywords: nlrp3 associated; somatic mosaic; associated autoinflammatory; amyloidosis ... See more keywords
Lactoferrin Retargets Human Adenoviruses to TLR4 to Induce an Abortive NLRP3-Associated Pyroptotic Response in Human Phagocytes
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DOI: 10.3389/fimmu.2021.685218
Abstract: Despite decades of clinical and preclinical investigations, we still poorly grasp our innate immune response to human adenoviruses (HAdVs) and their vectors. In this study, we explored the impact of lactoferrin on three HAdV types… read more here.
Keywords: response; nlrp3 associated; human adenoviruses; response human ... See more keywords
Behçet's Syndrome in a Chinese Pedigree of NLRP3-Associated Autoinflammatory Disease: A Coexistence or Novel Presentation?
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DOI: 10.3389/fmed.2021.695197
Abstract: Objectives: NLRP3-associated autoinflammatory disease (NLRP3-AID) and Behçet's syndrome (BS) both belong to autoinflammatory diseases and rarely co-occur. Here we reported a Chinese pedigree of NLRP3-AID presented with BS. Methods: We recorded a Chinese pedigree of… read more here.
Keywords: nlrp3 aid; chinese pedigree; nlrp3 associated; pedigree nlrp3 ... See more keywords