E3 ubiquitin ligase TRIM24 deficiency promotes NLRP3/caspase‐1/IL‐1β‐mediated pyroptosis in endometriosis
Sign Up to like & getrecommendations! Published in 2021 at "Cell Biology International"
DOI: 10.1002/cbin.11592
Abstract: Endometriosis is an inflammation‐dependent disease that shares similarities with malignant tumors including attachment and infiltration. Tripartite motif‐containing 24 (TRIM24) has been illustrated in inflammatory responses and gynecological tumors, and Nod‐like receptor protein 3 (NLRP3) inflammasome… read more here.
Keywords: trim24; nlrp3 caspase; endometriosis; mediated pyroptosis ... See more keywords
Pterostilbene inhibits amyloid‐β‐induced neuroinflammation in a microglia cell line by inactivating the NLRP3/caspase‐1 inflammasome pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27023
Abstract: Neuroinflammation has been known as an important pathogenetic contributor of Alzheimer's disease (AD). Pterostilbene is a natural compound which has neuroprotective activity. However, the effect of pterostilbene on amyloid‐β (Aβ)‐induced neuroinflammation has not been clarified.… read more here.
Keywords: nlrp3 caspase; caspase inflammasome; neuroinflammation; induced neuroinflammation ... See more keywords
Natural swietenine attenuates diabetic nephropathy by regulating the NF‐κB/NLRP3/Caspase‐1 signaling pathways: In vivo and in vitro study
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23653
Abstract: Swietenine (Swi), isolated from Swietenia macrophylla King ameliorates inflammation and oxidative stress, and diabetic nephropathy has a close connection with them. So the effects of Swi on diabetic nephropathy and its mechanism of action was… read more here.
Keywords: nlrp3 caspase; diabetic nephropathy; expression nlrp3;
Involvement of NLRP3/Caspase-1/GSDMD-Dependent Pyroptosis in BPA-Induced Apoptosis of Human Neuroblastoma Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2022.115042
Abstract: Bisphenol A (BPA) induces neurotoxicity via enhancing cell apoptosis and inflammation potently (effective at nanomolar concentrations), but its mechanisms remain unidentified. In this study, human neuroblastoma cell lines, IMR-32 and SK-N-SH cells, isolated from a… read more here.
Keywords: caspase gsdmd; nlrp3 caspase; caspase; apoptosis ... See more keywords
Deficiency of tenascin-C attenuated cardiac injury by inactivating TLR4/NLRP3/caspase-1 pathway after myocardial infarction.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2021.110084
Abstract: Inflammation and pyroptosis play a deleterious role in cardiac dysfunction after myocardial infarction (MI). NLRP3/caspase-1 is a well-established axis in pyroptosis and inflammation. In this study, we examined the effects of TN-C on pyroptosis through… read more here.
Keywords: caspase; inactivating tlr4; nlrp3 caspase; pyroptosis ... See more keywords
MiR-135b protects cardiomyocytes from infarction through restraining the NLRP3/caspase-1/IL-1β pathway.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2019.09.055
Abstract: BACKGROUND Myocardial infarction (MI) is the most common cause of cardiovascular morbidity and mortality worldwide. Despite the identification of many pathogenic genes associated with MI, the underlying molecular mechanisms remain poorly understood. MicroRNAs (miRNAs, miRs),… read more here.
Keywords: caspase; nlrp3 caspase; caspase pathway; infarction ... See more keywords
IP3R1 regulates Ca2+ transport and pyroptosis through the NLRP3/Caspase-1 pathway in myocardial ischemia/reperfusion injury
Sign Up to like & getrecommendations! Published in 2021 at "Cell Death Discovery"
DOI: 10.1038/s41420-021-00404-4
Abstract: Intracellular ion channel inositol 1,4,5-triphosphate receptor (IP3R1) releases Ca 2+ from endoplasmic reticulum. The disturbance of IP3R1 is related to several neurodegenerative diseases. This study investigated the mechanism of IP3R1 in myocardial ischemia/reperfusion (MI/R). After… read more here.
Keywords: nlrp3 caspase; ip3r1; pyroptosis; reperfusion ... See more keywords
Astragaloside IV ameliorate acute alcohol-induced liver injury in mice via modulating gut microbiota and regulating NLRP3/caspase-1 signaling pathway
Sign Up to like & getrecommendations! Published in 2023 at "Annals of Medicine"
DOI: 10.1080/07853890.2023.2216942
Abstract: Abstract Purpose Astragaloside IV (AS-IV) is a natural saponin substance extracted from the plant Radix Astragali with anti-inflammatory, antioxidant, anti-apoptotic, and liver-protecting effects. This study was to evaluate the liver protection effect of AS-IV on… read more here.
Keywords: nlrp3 caspase; acute alcohol; gut microbiota;
Uranium induces kidney cells pyroptosis in culture involved in ROS/NLRP3/caspase-1 signaling
Sign Up to like & getrecommendations! Published in 2022 at "Free Radical Research"
DOI: 10.1080/10715762.2022.2032021
Abstract: Abstract Pyroptosis is an exceptional mode of inflammation and programmed cell death involved in inflammasomes and Caspase-1 activation and inflammatory cytokines releasing. Our goal is to explore whether uranium (U)-intoxication could induce NRK-52E cells pyroptosis… read more here.
Keywords: nlrp3 caspase; ros nlrp3; pyroptosis; nrk 52e ... See more keywords
Pulsed electromagnetic field alleviates synovitis and inhibits the NLRP3/Caspase-1/GSDMD signaling pathway in osteoarthritis rats
Sign Up to like & getrecommendations! Published in 2022 at "Electromagnetic Biology and Medicine"
DOI: 10.1080/15368378.2021.2021933
Abstract: ABSTRACT Low-grade inflammation is a key mediator of the pathogenesis of Osteoarthritis (OA). Pulsed electromagnetic field (PEMF) can improve the symptoms of OA and potentially acts as an anti-inflammatory. The aim of this study was… read more here.
Keywords: nlrp3 caspase; gsdmd signaling; caspase gsdmd; pemf ... See more keywords
Critical role of NLRP3-caspase-1 pathway in age-dependent isoflurane-induced microglial inflammatory response and cognitive impairment
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-018-1137-1
Abstract: BackgroundElderly patients are more likely to suffer from postoperative cognitive dysfunction (POCD) after surgery and anesthesia. Except for declined organ function, the particular pathogenesis of POCD in elderly patients remains unknown. This study is carried… read more here.
Keywords: nlrp3 caspase; caspase pathway; isoflurane induced; cognitive impairment ... See more keywords