Qing-Re-Xing-Yu decoction confers intestinal barrier protection by reducing epithelial cell pyroptosis in experimental ulcerative colitis based on a NLRP3-GSDMD axis-dependent mechanism
Sign Up to like & getrecommendations! Published in 2021 at "Phytomedicine"
DOI: 10.1016/j.phymed.2021.153725
Abstract: Abstract Background Ulcerative colitis (UC) is a chronic inflammatory disease afflicting the colon, showing a rising incidence worldwide. Chinese medicinal formulae have been identified to be effective for the clinical treatment of UC yet the… read more here.
Keywords: nlrp3 gsdmd; qrxy decoction; decoction; intestinal barrier ... See more keywords
Epoxy Triglyceride Enhances Intestinal Permeability via Caspase-1/NLRP3/GSDMD and cGAS-STING Pathways in Dextran Sulfate Sodium-Induced Colitis Mice.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c08134
Abstract: Oxidized triglyceride monomers are the main cytotoxic products of deep-frying oil. However, its impact on the intestinal barrier, the first health guardian, remains unknown. In this study, HPLC-MS/MS analysis revealed that the epoxy group is… read more here.
Keywords: nlrp3 gsdmd; cgas sting; caspase nlrp3;
Hemoglobin Derived from Subarachnoid Hemorrhage-Induced Pyroptosis of Neural Stem Cells via ROS/NLRP3/GSDMD Pathway
Sign Up to like & getrecommendations! Published in 2023 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2023/4383332
Abstract: Accumulating evidence has demonstrated that neural stem cells (NSCs) have regenerative capacity after brain injuries, such as in aneurysmal subarachnoid hemorrhage (SAH). The reactive oxygen species (ROS)-induced NOD-like receptor thermal protein domain associated protein 3… read more here.
Keywords: induced pyroptosis; neural stem; subarachnoid hemorrhage; pyroptosis ... See more keywords
Knocking down GALNT6 promotes pyroptosis of pancreatic ductal adenocarcinoma cells through NF-κB/NLRP3/GSDMD and GSDME signaling pathway
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1097772
Abstract: Background Pancreatic ductal adenocarcinoma (PDAC), the most prevalent type of pancreatic cancer, is a highly lethal malignancy with poor prognosis. Polypeptide N-acetylgalactosaminyltransferase-6 (GALNT6) is frequently overexpressed in PDAC. However, the role of GALNT6 in the… read more here.
Keywords: galnt6; nlrp3 gsdmd; gsdme; expression ... See more keywords