A Pellino‐2 variant is associated with constitutive NLRP3 inflammasome activation in a family with ocular pterygium–digital keloid dysplasia
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Letters"
DOI: 10.1002/1873-3468.14597
Abstract: Ocular pterygium–digital keloid dysplasia (OPDKD) is a rare hereditary disease characterized by corneal ingrowth of vascularized conjunctival tissue early in life. Later, patients develop keloids on fingers and toes but are otherwise healthy. In a… read more here.
Keywords: keloid dysplasia; pellino; pterygium digital; ocular pterygium ... See more keywords
UK5099 Inhibits the NLRP3 Inflammasome Independently of its Long‐Established Target Mitochondrial Pyruvate Carrier
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202307224
Abstract: Targeting NLRP3 inflammasome has been recognized as a promising therapeutic strategy for the treatment of numerous common diseases. UK5099, a long‐established inhibitor of mitochondrial pyruvate carrier (MPC), is previously found to inhibit macrophage inflammatory responses… read more here.
Keywords: long established; pyruvate carrier; mitochondrial pyruvate; nlrp3 inflammasome ... See more keywords
MCC950 as a promising candidate for blocking NLRP3 inflammasome activation: A review of preclinical research and future directions
Sign Up to like & getrecommendations! Published in 2024 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202400459
Abstract: The NOD‐like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome is a key component of the innate immune system that triggers inflammation and pyroptosis and contributes to the development of several diseases. Therefore, blocking… read more here.
Keywords: candidate blocking; review; activation; nlrp3 inflammasome ... See more keywords
Interaction Between Autophagy and the Inflammasome in Human Tumors: Implications for the Treatment of Human Cancers
Sign Up to like & getrecommendations! Published in 2024 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.70035
Abstract: Autophagy is a physiologically regulated cellular process orchestrated by autophagy‐related genes (ATGs) that, depending on the tumor type and stage, can either promote or suppress tumor growth and progression. It can also modulate cancer stem… read more here.
Keywords: cancer; treatment; nlrp3 inflammasome; interaction autophagy ... See more keywords
USP9X promotes lipopolysaccharide‐stimulated acute lung injury by deubiquitination of NLRP3
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11932
Abstract: Alveolar epithelial cells (AECs) function as a vital defense barrier avoiding the invasion of exogenous agents and preserving the functional and structural integrity of lung tissues, while damage/breakdown of this airway epithelial barrier is frequently… read more here.
Keywords: acute lung; lung injury; pyroptosis; lung ... See more keywords
Hydrogen sulfide exposure induces NLRP3 inflammasome‐dependent IL‐1β and IL‐18 secretion in human mononuclear leukocytes in vitro
Sign Up to like & getrecommendations! Published in 2017 at "Clinical and Experimental Dental Research"
DOI: 10.1002/cre2.69
Abstract: The aim was to investigate if hydrogen sulfide (H2S) induces the formation of the NLRP3 inflammasome and subsequent IL‐1β and IL‐18 secretion in human peripheral blood mononuclear cells (PBMCs) and in the human monocyte cell… read more here.
Keywords: secretion; dependent secretion; secretion human; nlrp3 inflammasome ... See more keywords
Berberine ameliorates pulmonary inflammation in mice with influenza viral pneumonia by inhibiting NLRP3 inflammasome activation and gasdermin D‐mediated pyroptosis
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21995
Abstract: Viral pneumonia is a common complication caused by Influenza A virus infection and is characterized by severe pulmonary inflammation. A previous study showed that berberine (BBR) significantly ameliorated the pulmonary inflammation in mice with influenza… read more here.
Keywords: pulmonary inflammation; viral pneumonia; activation; nlrp3 inflammasome ... See more keywords
NLRP3 inflammasome triggers interleukin‐37 release from human monocytes
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202149724
Abstract: IL‐37 is an anti‐inflammatory member of the IL‐1 family that dampens inflammation associated with many noncommunicable diseases. However, mechanisms of IL‐37 regulation remain understudied. We aimed to investigate the enzymatic cleavage of IL‐37 that potentiates… read more here.
Keywords: cleavage; inflammasome triggers; secretion; release ... See more keywords
ATG16L2 inhibits NLRP3 inflammasome activation through promoting ATG5‐12‐16L1 complex assembly and autophagy
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202149764
Abstract: NLRP3 inflammasome activation is regulated by autophagy, a process tightly controlled by the ATG16L family proteins. However, the inside mechanisms remain elusive. Although the autophagy‐related protein ATG16L1 has been well characterized, regulation and biological functions… read more here.
Keywords: atg5 16l1; 16l1 complex; inflammasome activation; complex assembly ... See more keywords
mTOR Modulates NLRP3 Inflammasome Activation via Nuclear Translocation and STAT1 Inhibition
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Immunology"
DOI: 10.1002/eji.202451176
Abstract: The NLRP3 inflammasome has emerged as an unexpected sensor of metabolic danger and stress. Their enhanced activation has been implicated in the development of major diseases such as gout, Type 2 diabetes, obesity, cancer, and… read more here.
Keywords: inflammasome activation; activation; nlrp3 inflammasome; rapamycin ... See more keywords
Human immunodeficiency virus Type‐1 single‐stranded RNA activates the NLRP3 inflammasome and impairs autophagic clearance of damaged mitochondria in human microglia
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23568
Abstract: Despite the availability of antiretroviral therapy (ART) that fully suppresses human immunodeficiency virus type‐1 (HIV), markers of inflammation and minor neurocognitive impairment are frequently identified in HIV‐infected persons. Increasing data support that low‐level replication defective… read more here.
Keywords: single stranded; human immunodeficiency; virus type; immunodeficiency virus ... See more keywords