A Pellino‐2 variant is associated with constitutive NLRP3 inflammasome activation in a family with ocular pterygium–digital keloid dysplasia
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Letters"
DOI: 10.1002/1873-3468.14597
Abstract: Ocular pterygium–digital keloid dysplasia (OPDKD) is a rare hereditary disease characterized by corneal ingrowth of vascularized conjunctival tissue early in life. Later, patients develop keloids on fingers and toes but are otherwise healthy. In a… read more here.
Keywords: keloid dysplasia; pellino; pterygium digital; ocular pterygium ... See more keywords
USP9X promotes lipopolysaccharide‐stimulated acute lung injury by deubiquitination of NLRP3
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11932
Abstract: Alveolar epithelial cells (AECs) function as a vital defense barrier avoiding the invasion of exogenous agents and preserving the functional and structural integrity of lung tissues, while damage/breakdown of this airway epithelial barrier is frequently… read more here.
Keywords: acute lung; lung injury; pyroptosis; lung ... See more keywords
Hydrogen sulfide exposure induces NLRP3 inflammasome‐dependent IL‐1β and IL‐18 secretion in human mononuclear leukocytes in vitro
Sign Up to like & getrecommendations! Published in 2017 at "Clinical and Experimental Dental Research"
DOI: 10.1002/cre2.69
Abstract: The aim was to investigate if hydrogen sulfide (H2S) induces the formation of the NLRP3 inflammasome and subsequent IL‐1β and IL‐18 secretion in human peripheral blood mononuclear cells (PBMCs) and in the human monocyte cell… read more here.
Keywords: secretion; dependent secretion; secretion human; nlrp3 inflammasome ... See more keywords
Berberine ameliorates pulmonary inflammation in mice with influenza viral pneumonia by inhibiting NLRP3 inflammasome activation and gasdermin D‐mediated pyroptosis
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21995
Abstract: Viral pneumonia is a common complication caused by Influenza A virus infection and is characterized by severe pulmonary inflammation. A previous study showed that berberine (BBR) significantly ameliorated the pulmonary inflammation in mice with influenza… read more here.
Keywords: pulmonary inflammation; viral pneumonia; activation; nlrp3 inflammasome ... See more keywords
NLRP3 inflammasome triggers interleukin‐37 release from human monocytes
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202149724
Abstract: IL‐37 is an anti‐inflammatory member of the IL‐1 family that dampens inflammation associated with many noncommunicable diseases. However, mechanisms of IL‐37 regulation remain understudied. We aimed to investigate the enzymatic cleavage of IL‐37 that potentiates… read more here.
Keywords: cleavage; inflammasome triggers; secretion; release ... See more keywords
ATG16L2 inhibits NLRP3 inflammasome activation through promoting ATG5‐12‐16L1 complex assembly and autophagy
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202149764
Abstract: NLRP3 inflammasome activation is regulated by autophagy, a process tightly controlled by the ATG16L family proteins. However, the inside mechanisms remain elusive. Although the autophagy‐related protein ATG16L1 has been well characterized, regulation and biological functions… read more here.
Keywords: atg5 16l1; 16l1 complex; inflammasome activation; complex assembly ... See more keywords
Human immunodeficiency virus Type‐1 single‐stranded RNA activates the NLRP3 inflammasome and impairs autophagic clearance of damaged mitochondria in human microglia
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23568
Abstract: Despite the availability of antiretroviral therapy (ART) that fully suppresses human immunodeficiency virus type‐1 (HIV), markers of inflammation and minor neurocognitive impairment are frequently identified in HIV‐infected persons. Increasing data support that low‐level replication defective… read more here.
Keywords: single stranded; human immunodeficiency; virus type; immunodeficiency virus ... See more keywords
The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23728
Abstract: Microglial NLRP3 inflammasome activation is emerging as a key contributor to neuroinflammation during neurodegeneration. Pathogenic protein aggregates such as β‐amyloid and α‐synuclein trigger microglial NLRP3 activation, leading to caspase‐1 activation and IL‐1β secretion. Both caspase‐1… read more here.
Keywords: microglial nlrp3; amyotrophic lateral; activation; nlrp3 inflammasome ... See more keywords
The two pore potassium channel THIK‐1 regulates NLRP3 inflammasome activation
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24174
Abstract: The NLRP3 (NLR family, pyrin domain containing 3) inflammasome is a multi‐protein complex responsible for the activation of caspase‐1 and the subsequent cleavage and activation of the potent proinflammatory cytokines IL‐1β and IL‐18, and pyroptotic… read more here.
Keywords: potassium; channel thik; inflammasome activation; activation ... See more keywords
α‐Mangostin protects lipopolysaccharide‐stimulated nucleus pulposus cells against NLRP3 inflammasome‐mediated apoptosis via the NF‐κB pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4306
Abstract: Intervertebral disc degeneration (IDD) is a common and chronic inflammatory disorder. α‐Mangostin exhibits a novel biological function against inflammation in various inflammatory diseases. Here, we aimed to explore the role of α‐mangostin in IDD using… read more here.
Keywords: apoptosis; expression; mangostin; nucleus pulposus ... See more keywords
Reactive oxygen species‐mediated activation of NLRP3 inflammasome associated with pyroptosis in Het‐1A cells induced by the co‐exposure of nitrosamines
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4332
Abstract: Nitrosamines were a class of important environmental carcinogens associated with digestive tract neoplasms. As the early toxic effect of nitrosamines, inflammatory response participated in the malignant transformation of cells and promoted the occurrence and development… read more here.
Keywords: reactive oxygen; activation nlrp3; oxygen species; exposure ... See more keywords