Sodium houttuyfonate attenuates neurological defects after traumatic brain injury in mice via inhibiting NLRP3 inflammasomes
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22850
Abstract: Sodium houttuyfonate (SH) is a chemical compound synthesized by houttuynin and sodium bisulfite. As it has antinflammatory effects, SH has been widely used to treat autoimmune diseases, including post events following traumatic brain injury (TBI).… read more here.
Keywords: traumatic brain; nlrp3 inflammasomes; sodium houttuyfonate; activation ... See more keywords
Exogenous nanoparticles and endogenous crystalline molecules as danger signals for the NLRP3 inflammasomes
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27475
Abstract: Inflammasome mechanisms are involved as some of the pathways of sterile inflammation. Inflammasomes are large multiprotein complexes in the cytosol and are a key system for the production of the pivotal inflammatory cytokines, interleukin (IL)‐1β… read more here.
Keywords: danger signals; nlrp3 inflammasomes; inflammation; endogenous crystalline ... See more keywords
Protraction of neuropathic pain by morphine is mediated by spinal damage associated molecular patterns (DAMPs) in male rats
Sign Up to like & getrecommendations! Published in 2018 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2017.08.018
Abstract: We have recently reported that a short course of morphine, starting 10days after sciatic chronic constriction injury (CCI), prolonged the duration of mechanical allodynia for months after morphine ceased. Maintenance of this morphine-induced persistent sensitization… read more here.
Keywords: associated molecular; morphine; nlrp3 inflammasomes; molecular patterns ... See more keywords
MicroNAR-194-5p hinders the activation of NLRP3 inflammasomes and alleviates neuroinflammation during intracerebral hemorrhage by blocking the interaction between TRAF6 and NLRP3
Sign Up to like & getrecommendations! Published in 2021 at "Brain Research"
DOI: 10.1016/j.brainres.2020.147228
Abstract: The possible role of miR-194-5p in brain and neurodegenerative diseases has been reported, but its role in intracerebral hemorrhage (ICH) has not been studied. This study estimated the mechanism of miR-194-5p in ICH. ICH rat… read more here.
Keywords: traf6 nlrp3; traf6; nlrp3 inflammasomes; activation nlrp3 ... See more keywords
NLRP3 inflammasomes that induce antitumor immunity.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in immunology"
DOI: 10.1016/j.it.2021.05.001
Abstract: Inflammasomes have emerged as context-dependent regulators of inflammation and protective immunity in vertebrates. Depending on the cell type and stimulus, inflammasome activities lead to interleukin (IL)-1 release from living (hyperactive) or dead (pyroptotic) cells. Herein,… read more here.
Keywords: immunity; induce antitumor; antitumor immunity; nlrp3 inflammasomes ... See more keywords
Amyloid‐β activates NLRP3 inflammasomes by affecting microglial immunometabolism through the Syk‐AMPK pathway
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13623
Abstract: Neuroinflammation is considered one of major factors in the pathogenesis of Alzheimer's disease (AD). In particular, inflammasome activation, including NLRP3 inflammasome in microglia, is regarded as fundamental for the pro‐inflammatory response of immune cells. However,… read more here.
Keywords: syk ampk; amyloid activates; activates nlrp3; nlrp3 inflammasomes ... See more keywords
IL-1α and TNF-α as an inducer for ROS-mediated NLRP1/NLRP3 inflammasomes activation in mononuclear blood cells from individuals with chronic insomnia disorder.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of neurology"
DOI: 10.1111/ene.15540
Abstract: BACKGROUND There are some evidence that cytokines may play an important role in sleep deprivation; however, the underlying mechanisms are still unknown. So, the present study aim to evaluate the relationship between NLRP1 and NLRP3… read more here.
Keywords: nlrp1 nlrp3; blood cells; nlrp3 inflammasomes; individuals cid ... See more keywords
Immunoproteasome modulates NLRP3 inflammasome‐mediated neuroinflammation under cerebral ischaemia and reperfusion conditions
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17104
Abstract: Compelling evidence showed that both nucleotide‐binding oligomerization domain‐like receptor family, pyrin domain‐containing protein 3 (NLRP3) inflammasomes and the immunoproteasome participate in neuroinflammatory responses in cerebral ischaemia injury. Moreover, inhibition of either NLRP3 inflammasomes or the… read more here.
Keywords: nlrp3 inflammasome; immunoproteasome modulates; modulates nlrp3; nlrp3 inflammasomes ... See more keywords
Hedgehog-induced ZFYVE21 promotes chronic vascular inflammation by activating NLRP3 inflammasomes in T cells
Sign Up to like & getrecommendations! Published in 2023 at "Science Signaling"
DOI: 10.1126/scisignal.abo3406
Abstract: The zinc finger protein ZFYVE21 is involved in immune signaling. Using humanized mouse models, primary human cells, and patient samples, we identified a T cell–autonomous role for ZFYVE21 in promoting chronic vascular inflammation associated with… read more here.
Keywords: inflammation; vascular inflammation; chronic vascular; nlrp3 inflammasomes ... See more keywords
In Silico Structural and Functional Analyses of NLRP3 Inflammasomes to Provide Insights for Treating Neurodegenerative Diseases
Sign Up to like & getrecommendations! Published in 2023 at "BioMed Research International"
DOI: 10.1155/2023/9819005
Abstract: Inflammasomes are cytoplasmic intracellular multiprotein complexes that control the innate immune system's activation of inflammation in response to derived chemicals. Recent advancements increased our molecular knowledge of activation of NLRP3 inflammasomes. Although several studies have… read more here.
Keywords: silico structural; functional analyses; analyses nlrp3; nlrp3 inflammasomes ... See more keywords
A novel optical imaging probe for targeted visualization of NLRP3 inflammasomes in a mouse model of age-related macular degeneration
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.1047791
Abstract: Purpose Wet form of age-related macular degeneration (wet AMD) is a progressive vascular disease that mainly affects older adults and causes severe and irreversible vision loss. A key complication of wet AMD is choroidal neovascularization… read more here.
Keywords: age related; imaging probe; nlrp3 inflammasomes; inflammaprobe ... See more keywords