Efficacy of novel selective NLRP3 inhibitors in human and murine retinal pigment epithelial cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-019-01753-5
Abstract: NLRP3 inflammasome activation in the retinal pigment epithelium (RPE) is observed in atrophic age-related macular degeneration (AMD), and pharmacological NLRP3 inhibition may provide a therapeutic strategy to halt disease progression. We tested selective NLRP3 inhibitors… read more here.
Keywords: human murine; inflammasome activation; nlrp3 inhibitors; activation ... See more keywords
1,2,4-Triazine Derivatives as NLRP3 Inhibitors for Treating Diseases.
Sign Up to like & getrecommendations! Published in 2023 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.3c00122
Abstract: Provided herein are 1,2,4-triazine derivatives used as NLRP3 inhibitors, their pharmaceutical compositions, the use of such compounds in treating diseases and processes for preparing such compounds. read more here.
Keywords: treating diseases; chemistry; derivatives nlrp3; inhibitors treating ... See more keywords
A Selective Review and Virtual Screening Analysis of Natural Product Inhibitors of the NLRP3 Inflammasome
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27196213
Abstract: The NLRP3 inflammasome is currently an exciting target for drug discovery due to its role in various inflammatory diseases; however, to date, no NLRP3 inhibitors have reached the clinic. Several studies have used natural products… read more here.
Keywords: selective review; review virtual; nlrp3 inhibitors; natural product ... See more keywords