TIMP2 facilitates CIRI through activating NLRP3-mediated pyroptosis.
Sign Up to like & getrecommendations! Published in 2023 at "Aging"
DOI: 10.18632/aging.204696
Abstract: This study aimed to investigate the underlying mechanisms of cerebral ischemia-reperfusion injury (CIRI) in mice using CIR and hypoxia/reoxygenation (H/R) cell models. The study evaluated brain tissue weight, pathological injury, and changes in the expression… read more here.
Keywords: brain; group; mediated pyroptosis; timp2 group ... See more keywords
NLRP3-mediated pyroptosis in diabetic nephropathy
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DOI: 10.3389/fphar.2022.998574
Abstract: Diabetic nephropathy (DN) is the main cause of end-stage renal disease (ESRD), which is characterized by a series of abnormal changes such as glomerulosclerosis, podocyte loss, renal tubular atrophy and excessive deposition of extracellular matrix.… read more here.
Keywords: pyroptosis; pyroptosis diabetic; mediated pyroptosis; diabetic nephropathy ... See more keywords
Targeting NLRP3-Mediated Neuroinflammation in Alzheimer’s Disease Treatment
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DOI: 10.3390/ijms23168979
Abstract: Alzheimer’s disease (AD) is the most common cause of dementia in the general population and, to date, constitutes a major therapeutic challenge. In the pathogenesis of AD, aggregates of amyloid β (Aβ) and neurofibrillary tangles… read more here.
Keywords: mediated neuroinflammation; alzheimer disease; pathology; targeting nlrp3 ... See more keywords