Epigenetics and expression of key genes associated with cardiac fibrosis: NLRP3, MMP2, MMP9, CCN2/CTGF and AGT.
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DOI: 10.2217/epi-2020-0446
Abstract: Aims: Excessive inflammatory signaling and pathological remodeling of the extracellular matrix drive cardiac fibrosis and require changes in gene expression. Materials and methods: Using bioinformatics, both tissue-specific expression profiles and epigenomic profiles of some genes critical for cardiac… read more here.
Keywords: mmp9 ccn2; fibrosis; cardiac fibrosis; ccn2 ctgf ... See more keywords