Selenium Attenuates Doxorubicin-Induced Cardiotoxicity Through Nrf2-NLRP3 Pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Biological trace element research"
DOI: 10.1007/s12011-021-02891-z
Abstract: Selenium (Se), an essential nutrient for humans, has been reported to possess cardioprotective effect. However, the protective effects of Se against doxorubicin (DOX)-induced cardiotoxicity and the underlying mechanism are rarely reported. In this study, we… read more here.
Keywords: dox induced; nrf2 nlrp3; induced cardiotoxicity; nlrp3 pathway ... See more keywords
FNDC5 induces M2 macrophage polarization and promotes hepatocellular carcinoma cell growth by affecting the PPARγ/NF-κB/NLRP3 pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.10.041
Abstract: PURPOSE The purpose of this study was to investigate the effect of FNDC5 expression levels in hepatocellular carcinoma on the phenotypic changes of macrophages in tumor tissues. METHODS In this study, we established an in vitro… read more here.
Keywords: hepatocellular carcinoma; carcinoma; affecting ppar; carcinoma cells ... See more keywords
Inhibition of P2X7 Purinergic Receptor Ameliorates Cardiac Fibrosis by Suppressing NLRP3/IL-1β Pathway
Sign Up to like & getrecommendations! Published in 2020 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2020/7956274
Abstract: P2X7 purinergic receptor (P2X7R) has been implicated in several cardiovascular diseases. However, whether it regulates cardiac fibrosis remains elusive. Herein, its involvement in the development of cardiac fibrosis was examined using a transverse aortic constriction… read more here.
Keywords: fibrosis; cardiac fibrosis; purinergic receptor; p2x7 purinergic ... See more keywords
IL-12 Contributes to the Development of Asthma by Targeting HIF-1α/NLRP3 Pathway through Runx3
Sign Up to like & getrecommendations! Published in 2022 at "International Archives of Allergy and Immunology"
DOI: 10.1159/000526803
Abstract: Introduction: The aim of the study was to determine the role and mechanism of runt-related transcription factor 3 (Runx3) in the development of asthma. Methods: An asthma mouse model was constructed and validated by hematoxylin-eosin… read more here.
Keywords: development asthma; hif nlrp3; runx3; nlrp3 pathway ... See more keywords
FERMT1 knockdown attenuates inflammation induced by intracerebral hemorrhage in rats via NLRP3/NF-κB pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Experimental animals"
DOI: 10.1538/expanim.22-0145
Abstract: Intracerebral hemorrhage (ICH) is an incurable neurological disease. Microglia activation and its related inflammation contribute to ICH-associated brain damage. FERM domain containing kindlin 1 (FERMT1) is an integrin-binding protein that participates in microglia-associated inflammation, but… read more here.
Keywords: inflammation; nlrp3 pathway; fermt1 knockdown; via nlrp3 ... See more keywords
Activating SIRT1 deacetylates NF-κB p65 to alleviate liver inflammation and fibrosis via inhibiting NLRP3 pathway in macrophages
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Medical Sciences"
DOI: 10.7150/ijms.77955
Abstract: Background and aims: Macrophages play a critical role in the development of liver diseases. As an NAD+-dependent histone deacetylase, SIRT1 inhibits liver inflammation and fibrosis, but the mechanisms are not fully understood. Our aim was… read more here.
Keywords: inflammation; nlrp3 pathway; inflammation fibrosis; liver inflammation ... See more keywords