Ferulic acid relieved ulcerative colitis by inhibiting the TXNIP/NLRP3 pathway in rats
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11935
Abstract: Ulcerative colitis (UC) is a disorder of the bowel that is characterized by a chronic inflammatory response. The traditional Chinese herbal medicine ferulic acid (FA) is known for its antioxidant, antiapoptotic, and antiinflammatory properties. However,… read more here.
Keywords: nlrp3 signaling; ulcerative colitis; pathway; txnip nlrp3 ... See more keywords
Tetrahydropalmatine induces the polarization of M1 macrophages to M2 to relieve limb ischemia‐reperfusion‐induced lung injury via inhibiting the TLR4/NF‐κB/NLRP3 signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21965
Abstract: Tetrahydropalmatine (THP) is the main component of the Chinese medicine Corydalis yanhusuo, which has been reported to alleviate limb ischemia‐reperfusion‐induced acute lung injury (LIR‐ALI). This study aimed to investigate the mechanism underlying the effect of… read more here.
Keywords: lir ali; nlrp3 signaling; expression; polarization ... See more keywords
FOXC1 Aggravates the Ischemia‐Reperfusion Induced Injury in Renal Tubular Epithelial Cells by Activating NF‐κB/NLRP3 Signaling
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.70301
Abstract: Renal ischemia‐reperfusion injury (RIRI) is a condition characterized by inflammation and cell damage in the kidneys following a period of ischemia and subsequent reperfusion, which lacks effective treating method in the clinic. Exploring molecular mechanisms… read more here.
Keywords: induced injury; ischemia reperfusion; foxc1; injury renal ... See more keywords
ROS–NLRP3 signaling pathway induces sterile inflammation after thulium laser resection of the prostate
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30663
Abstract: The sterile inflammation (SI) of the urinary tract is a common problem requiring serious consideration after prostatectomy. This study mainly focuses on the role of the reactive oxygen species–NLR family, pyrin domain‐containing 3 (ROS–NLRP3) signaling… read more here.
Keywords: ros nlrp3; sterile inflammation; signaling pathway; nlrp3 signaling ... See more keywords
Artemisinin Alleviates Chronic Social Defeat Stress‐Induced Depressive‐Like Behavior by Inhibiting Neuroinflammation via the TLR4/MyD88/NF‐κB/NLRP3 Signaling Pathway
Sign Up to like & getrecommendations! Published in 2025 at "Phytotherapy Research"
DOI: 10.1002/ptr.70106
Abstract: Neuroinflammation caused by neuroimmune dysfunction is important for the pathogenesis of major depressive disorders; new antidepressant treatments are urgently needed. Artemisinin (ART) has anti‐inflammatory and neuroprotective effects; it can alleviate the inflammatory response in the… read more here.
Keywords: tlr4 myd88; like behavior; neuroinflammation; signaling pathway ... See more keywords
Ruscogenin Exerts Anxiolytic‐Like Effect via Microglial NF‐κB/MAPKs/NLRP3 Signaling Pathways in Mouse Model of Chronic Inflammatory Pain
Sign Up to like & getrecommendations! Published in 2024 at "Phytotherapy Research"
DOI: 10.1002/ptr.8325
Abstract: Long‐term inflammation can cause chronic pain and trigger patients' anxiety by sensitizing the central nervous system. However, effective drugs with few side effects for treating chronic pain‐induced anxiety are still lacking. The anxiolytic and anti‐inflammatory… read more here.
Keywords: signaling pathways; pain; mapks nlrp3; inflammatory ... See more keywords
Suppression of NLRP3 and NF-κB signaling pathways by α-Cyperone via activating SIRT1 contributes to attenuation of LPS-induced acute lung injury in mice.
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.105886
Abstract: α-Cyperone is the volatile oil component in Cyperus rotundus L. The previous reports had shown the inhibition of α-Cyperone on NF-κB signaling in LPS-stimulated RAW264.7 cells. However, it is still unclear whether α-Cyperone could suppress… read more here.
Keywords: nlrp3 signaling; signaling pathways; lps induced; cyperone ... See more keywords
Cucurbitacin E glucoside alleviates concanavalin A-induced hepatitis through enhancing SIRT1/Nrf2/HO-1 and inhibiting NF-ĸB/NLRP3 signaling pathways.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2022.115223
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Cucurbitacins are highly oxygenated tetracyclic triterpenoids, that represent the major metabolites reported from C. colocynthis (L.) Schrad.. Cucurbitacin E glucoside (CuE) is a tetracyclic triterpene glycoside separated from Cucurbitaceae plants. CuE has potent… read more here.
Keywords: cue; sirt1 nrf2; nlrp3 signaling; cucurbitacin glucoside ... See more keywords
Mechanistic Insights into T-2 Toxin-Induced Thymic Epithelial Cell Injury and Immunotoxicity via the ROS-NF-κB-NLRP3 Signaling Axis.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.5c00355
Abstract: Thymic epithelial cells (TECs) are critical for thymic structure and function, yet the impact of T-2 toxin (T-2) on TECs and related molecular pathways remains unclear. This study sheds light on the mechanisms of T-2-induced… read more here.
Keywords: induced thymic; signaling axis; thymic epithelial; injury ... See more keywords
Melatonin alleviates chronic stress-induced hippocampal microglia pyroptosis and subsequent depression-like behaviors by inhibiting Cathepsin B/NLRP3 signaling pathway in rats
Sign Up to like & getrecommendations! Published in 2024 at "Translational Psychiatry"
DOI: 10.1038/s41398-024-02887-y
Abstract: Melatonin improves chronic stress-induced hippocampal damage and depression-like behaviors, but the mechanism needs further study. This study was to explore the mechanism of melatonin inhibiting microglia pyroptosis. In virtro experiments, melatonin improved corticosterone-induced the ultrastructure… read more here.
Keywords: pyroptosis; cathepsin nlrp3; microglia pyroptosis; signaling pathway ... See more keywords
Aprepitant alleviates acute lung injury in a rat model of hepatic ischemia–reperfusion via NLRP3/IL-1β signaling pathway
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-25930-4
Abstract: Hepatic ischemia reperfusion (HIR) injury is a complication that complicates major liver surgeries and contributes to significant hepatic and remote organs damage. Aprepitant (Ap), a neurokinin-1 receptor (NK-1R) antagonists, is an antiemetic commonly used in… read more here.
Keywords: hepatic ischemia; lung; reperfusion; signaling pathway ... See more keywords