NLS-RARα blocks cell differentiation by inhibiting the retinoic acid signalling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.05.076
Abstract: A majority of acute promyelocytic leukaemia (APL) cases are characterized by the PML-RARα fusion gene. Previous studies have shown that neutrophil elastase (NE) can cleave PML-RARα and is important for the development of APL. Here,… read more here.
Keywords: rar; nls rar; cell differentiation; acid signalling ... See more keywords
Location of NLS-RARα protein in NB4 cell and nude mice
Sign Up to like & getrecommendations! Published in 2017 at "Oncology Letters"
DOI: 10.3892/ol.2017.5706
Abstract: In the majority of acute promyelocytic leukemia (APL) cases, translocons produce a promyelocytic leukemia protein-retinoic acid receptor α (PML-RARα) fusion gene. Studies have reported that neutrophil elastase (NE) cleaves bcr-1-derived PML-RAα in early myeloid cells,… read more here.
Keywords: rar; location nls; nls rar; rar protein ... See more keywords