Activation of 5-HT1A postsynaptic receptors by NLX-101 results in functional recovery and an increase in neuroplasticity in mice with brain ischemia
Sign Up to like & getrecommendations! Published in 2020 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2019.109832
Abstract: Pharmacological interventions that selectively activate serotonin 5-hydroxytryptramine-1A (5-HT1A) heteroreceptors may prevent or attenuate the consequences of brain ischemic episodes. The present study investigated whether the preferential 5-HT1A postsynaptic receptor agonist NLX-101 (a.k.a. F15599) mitigates cognitive… read more here.
Keywords: brain ischemia; neuroplasticity mice; brain; ht1a postsynaptic ... See more keywords
Cortical 5-hydroxytryptamine 1A receptor biased agonist, NLX-101, displays rapid-acting antidepressant-like properties in the rat chronic mild stress model
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Psychopharmacology"
DOI: 10.1177/0269881119860666
Abstract: Background: NLX-101 (also known as F15599) is a highly selective and efficacious ‘biased’ agonist at cortical 5-hydroxytryptamine 1A (5-HT1A) heteroreceptors. In rodents, it possesses marked antidepressant-like activity, potently and completely abolishing immobility in the forced… read more here.
Keywords: biased agonist; cortical hydroxytryptamine; model; rat chronic ... See more keywords
Molecular Signaling Mechanisms for the Antidepressant Effects of NLX-101, a Selective Cortical 5-HT1A Receptor Biased Agonist
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DOI: 10.3390/ph15030337
Abstract: Depression is the most prevalent of the mental illnesses and serotonin (5-hydroxytryptamine, 5-HT) is considered to be the major neurotransmitter involved in its etiology and treatment. In this context, 5-HT1A receptors have attracted interest as… read more here.
Keywords: ht1a; signaling mechanisms; antidepressant effects; molecular signaling ... See more keywords