Improvement of urethral dysfunction by 5‐HT1A receptor agonist NLX‐112 in diabetic rats
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DOI: 10.1002/nau.24993
Abstract: To examine the effects of the selective 5‐HT1A receptor agonist, NLX‐112, on urethral function in streptozotocin‐induced diabetic rats. read more here.
Keywords: diabetic rats; agonist nlx; ht1a receptor; nlx 112 ... See more keywords
Antinociceptive, antiallodynic and antihyperalgesic effects of the 5-HT1A receptor selective agonist, NLX-112 in mouse models of pain
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DOI: 10.1016/j.neuropharm.2017.07.022
Abstract: BACKGROUND AND PURPOSE NLX-112 (a.k.a. befiradol, F13640) is a drug candidate intended for the treatment of l-DOPA-induced dyskinesia. It is a highly selective serotonin 5-HT1A receptor full agonist which has been previously tested in a… read more here.
Keywords: nlx 112; mouse models; ht1a receptor; pain ... See more keywords
NLX-112, a highly selective 5-HT1A receptor biased agonist, does not exhibit misuse potential in male rats or macaques
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DOI: 10.1016/j.neuropharm.2022.109025
Abstract: NLX-112 (a.k.a. F13640 or befiradol) exhibits nanomolar affinity, exceptional selectivity and biased agonism at serotonin 5-HT1A receptors. NLX-112 displays robust analgesic activity in a number of rodent models of pain, and is currently developed as… read more here.
Keywords: misuse potential; ht1a; nlx 112; icss ... See more keywords
The selective 5-HT1A receptor agonist, NLX-112, overcomes tetrabenazine-induced catalepsy and depression-like behavior in the rat
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DOI: 10.1097/fbp.0000000000000681
Abstract: Tetrabenazine, a preferential inhibitor of the vesicular monoamine transporter type 2, depletes the brain monoamines dopamine, serotonin and norepinephrine. Tetrabenazine and deutetrabenazine (Austedo ®) are used to treat chorea associated with Huntington’s disease. However, both… read more here.
Keywords: ht1a; agonist; nlx 112; induced catalepsy ... See more keywords