Systematic Kinase Inhibitor Profiling Identifies CDK9 as a Synthetic Lethal Target in NUT Midline Carcinoma
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DOI: 10.1016/j.celrep.2017.08.082
Abstract: Summary Kinase inhibitors represent the backbone of targeted cancer therapy, yet only a limited number of oncogenic drivers are directly druggable. By interrogating the activity of 1,505 kinase inhibitors, we found that BRD4-NUT-rearranged NUT midline… read more here.
Keywords: nut midline; kinase; midline carcinoma; nmc cells ... See more keywords